How Does Early Age Life Style Affect Bone Strength and General Health Parameters at Middle Age?
NCT ID: NCT00270608
Last Updated: 2007-11-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2007-03-31
2008-11-30
Brief Summary
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Detailed Description
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The purpose of the proposed research is to quantify the effect of life style on bone strength and general health parameters by comparing two male populations, one sedentary and the other that has done demanding physical training: (1) Elite infantry recruits who were inducted into the I.D.F. in Feb 1983, did their basic training at Sanur and were part of the 1983 stress fracture project who completed three years of elite infantry service and continued to serve as combat soldiers in the reserves; (2) Yeshiva students who had profiles of 82 or 97 and received deferment from their military service in 1983 and since then have continued their studies and never served in the army.
50 subjects will be reviewed in each group. Measurements of weight, height, waist and abdominal girth, resting pulse and blood pressure will be made. The brachial/ankle blood pressure index will be recorded. MRI of the right knee to study potential degenerate changes will be done using a 1.5 Tesla General Electric Signa MR scanner. Quantitative Computed Tomography (QCT), one of the most popular and effective methods utilized for osteoporosis screening, will be performed to determine volumetric BMD, BMC, bone geometric properties and strength indexes of the tibia and lumbar spine.
Comparisons:
Group I: 50 males (age 41-45), former elite Israeli infantry soldiers, selected randomly from those recruits who did their infantry basic training at Sanur in Feb. 1983 (all profiled 82 or 97) and completed their military service as combat soldiers will be compared to:
Group II: 50 age-, profile- and ethnically-matched Israeli citizens whose military service was deferred in 1983 because of Torah studies and who did not do army service and were not involved in any kind of physical training.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Quantitative Computed Tomography of the tibia and spine
a single time 1 minute procedure
MRI of the spine and the right knee
a single time 45 minutes procedure
Blood test
A single time procedure to check lipid profile and hemoglobin A1C
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Former soldiers with shrapnel injuries will be excluded from MRI studies
40 Years
45 Years
MALE
Yes
Sponsors
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Hadassah Medical Organization
OTHER
Principal Investigators
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Prof. Charles Milgrom, MD
Role: PRINCIPAL_INVESTIGATOR
Hadassah Medical Organization
Locations
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Hadassah Medical Organization
Jerusalem, , Israel
Countries
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Central Contacts
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Facility Contacts
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Arik Tzukert, DMD
Role: primary
Hadas Lemberg, PhD
Role: backup
References
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Milgrom C, Giladi M, Stein M, Kashtan H, Margulies JY, Chisin R, Steinberg R, Aharonson Z. Stress fractures in military recruits. A prospective study showing an unusually high incidence. J Bone Joint Surg Br. 1985 Nov;67(5):732-5. doi: 10.1302/0301-620X.67B5.4055871.
Other Identifiers
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12-17.02.06-HMO-CTIL
Identifier Type: -
Identifier Source: org_study_id