Clinical Observation on Bone Metabolism Induced by Chronic Renal Insufficiency
NCT ID: NCT02147782
Last Updated: 2021-09-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
300 participants
OBSERVATIONAL
2012-10-31
2022-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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control
Healthy people from physical examination centers are recruited as controls.
No interventions assigned to this group
CKD1
1. with clinical one or more symptoms and signs of kidney injury listed as below：
1. Urinary albumin ( urinary albumin excretion rate≥30 mg/24 h.albumin-creatinine ratio≥3mg/mmol)
2. urinary sediments abnormality
3. renal tubular lesions
4. renal histological abnormalities
5. abnormal structure showed by imaging
6. history of renal transplantation
2. GFR≥90（ml/min/1.73m²)
No interventions assigned to this group
CKD2
with clinical symptoms and signs of kidney injury, and 60\<=GFR\<=89（ml/min/1.73m²)
No interventions assigned to this group
CKD3
with clinical symptoms and signs of kidney injury, and 30\<=GFR\<=59（ml/min/1.73m²)
No interventions assigned to this group
CKD4
with clinical symptoms and signs of kidney injury, and 15\<=GFR\<=29（ml/min/1.73m²)
No interventions assigned to this group
CKD5
with clinical symptoms and signs of kidney injury, and GFR\<15（ml/min/1.73m²)
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
2. chronic renal insufficiency (Control: normal kidney function; Case: CKD 1-5)
3. be willing to and be able to join in the study and signed informed consent
4. have not accepted systematical treatment on bone loss or osteoporosis
Exclusion Criteria
2. secondary osteoporosis caused by other diseases.
3. postmenopausal women
4. mental illness or psychosis
5. patients with bone fracture and need surgery treatment
6. taking any medicine that will affect bone metabolism for a long time and can not stop
7. women during pregnant stage and breast-feed stage
8. with deformity or disability
20 Years
50 Years
ALL
Yes
Sponsors
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Anhui Provincial Hospital
OTHER_GOV
Huadong Hospital
OTHER
Longhua Hospital
OTHER
Shanghai University of Traditional Chinese Medicine
OTHER
Responsible Party
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Bing Shu
Associate Professor
Principal Investigators
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Yongjun Wang, Doctor
Role: PRINCIPAL_INVESTIGATOR
Shanhgai University of TCM
Locations
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Anhui Province Hospital of TCM
Hefei, Anhui, China
Jiangsu Province Hospital of TCM
Nanjing, Jiangsu, China
Longhua hospital affiliated to Shanghai University of TCM
Shanghai, Shanghai Municipality, China
Huadong Hospital Affiliated to Fudan University
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Shunjin Hu
Role: primary
Other Identifiers
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1RT1270,2010CB530400
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
Renal Osteodystrophy
Identifier Type: -
Identifier Source: org_study_id
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