The Increase Study. Effect of Incremental Versus Fixed Pump on Peak Oxygen Consumption in Heart Failure Patients Supported With a Continuous Flow Left Venticular Assist Device

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2012-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of the study is to examine the relationship between working capacity (peak oxygen consumption) and pump speed of continuous flow left ventricular assist devices (CF-LVADs)in heart failure patients. The hypothesis is that it is possible to increase peak oxygen consumption by incrementally increasing CF-LVAD pumpspeed during exercise.

The study population will consist of severe heart failure patients with CF-LVADs treated at The Heart Centre of Copenhagen University Hospital Rigshospitalet.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Pulmonary And Renal Support During Acute Respiratory Distress Syndrome

NCT01239966

Acute Respiratory Distress Syndrome Acute Renal Failure

COMPLETED PHASE3

Non-invasive Ventilation and High-speed Oxygen Therapy Effects on Heart Function - HiFlow-Heart Study

NCT04471129

Chronic Heart Failure

UNKNOWN NA

Exercise and Noninvasive Ventilation in Heart Failure Patients

NCT02085122

Heart Failure

COMPLETED NA

Dead Space Evaluation in Pulmonary Hypertension

NCT02892981

Pulmonary Hypertension

COMPLETED NA

Clinical Decision Support for Mechanical Ventilation of Patients With ARDS

NCT03984175

Acute Respiratory Distress Syndrome

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Heart Failure.

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

CF-LVAD pumpspeed.

Optimal pumpspeed setting of CF-LVAD during exercise on ergometric bicycle.

Group Type EXPERIMENTAL

Incremental pump speed of CF-LVAD.

Intervention Type DEVICE

Peak oxygen consumption with fixed versus incremental pump speed.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Incremental pump speed of CF-LVAD.

Peak oxygen consumption with fixed versus incremental pump speed.

Intervention Type DEVICE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

HeartMate II.

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* HeartMate II patients who underwent surgery and follow-up at The Heart Centre of Rigshospitalet.
* Heart failure in stable phase without the need for intravenous inotropic therapy.
* Ischemic and non-ischemic cardiomyopathy.