Dead Space Evaluation in Pulmonary Hypertension

NCT ID: NCT02892981

Last Updated: 2016-09-08

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 18 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-01-31
• Study Completion Date: 2016-04-30

Brief Summary

Aim of the study is to evaluate the role of chemoreceptor activity and ventilation perfusion mismatch on the genesis of exercise induced hyperventilation in Pulmonary hypertension patients. So the investigators tested the chemoreceptor response at rest, both with hypoxic and hypercapnic stimuli, and the ventilatory response during exercise analyzing its two components, alveolar and dead space ventilation.

Conditions

Pulmonary Hypertension

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Pulmonary hypertension patients

All Pulmonary hypertension patients enrolled in the study underwent a cardiopulmonary exercise test and hypoxia and hypercapnia tests

Group Type: OTHER

cardiopulmonary exercise test,hypoxia and hypercapnia test

Intervention Type: OTHER

class I and IV Pulmonary hypertension patients in stable haemodynamic status and optimized medical therapy underwent cardiopulmonary test and hypoxia and hypercapnia tests to evaluate the chemoreceptor sensitivity

Interventions

cardiopulmonary exercise test,hypoxia and hypercapnia test

class I and IV Pulmonary hypertension patients in stable haemodynamic status and optimized medical therapy underwent cardiopulmonary test and hypoxia and hypercapnia tests to evaluate the chemoreceptor sensitivity

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• age ≥18 and ≤ 80 years
• ability to understand the research protocol and willing to sign the study informed consent
• diagnosis of pulmonary arterial hypertension belonging to Class I and IV
• stable haemodynamic status and optimized medical treatment since at least 2 months
• ability to perform maximal cardiopulmonary exercise test and pulmonary diffusing capacity for carbon monoxide evaluation

Exclusion Criteria

• relevant comorbidities
• usual contraindications for cardiopulmonary exercise test
• pulmonary hypertension associated to left heart and pulmonary disease, congenital heart diseases with evident cardiac shunts.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Centro Cardiologico Monzino

OTHER

Sponsor Role: lead

Responsible Party

Piergiuseppe Agostoni

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

References

Farina S, Bruno N, Agalbato C, Contini M, Cassandro R, Elia D, Harari S, Agostoni P. Physiological insights of exercise hyperventilation in arterial and chronic thromboembolic pulmonary hypertension. Int J Cardiol. 2018 May 15;259:178-182. doi: 10.1016/j.ijcard.2017.11.023.

Reference Type: DERIVED

PMID: 29579597 (View on PubMed)

Other Identifiers

ccm257

Identifier Type: -

Identifier Source: org_study_id