Correlation Between Trans Esophageal Pressure and Non-invasive Respiratory Support Failure in Patients With Acute Hypoxic Respiratory Failure

NCT ID: NCT03826797

Last Updated: 2023-03-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-10-16

Study Completion Date

2027-12-31

Brief Summary

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This study aims at assessing the correlation between trans esophageal pressure and related respiratory mechanics (including, among others, nasal pressure-Pnose) and non-invasive respiratory support failure in patients with acute hypoxic respiratory failure of different etiology (including COVID-19).

Detailed Description

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Conditions

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Acute Respiratory Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Age \>18 years
* Acute hypoxic respiratory failure (P/F \< 200)

Exclusion Criteria

* Acute pulmonary edema
* Chest wall deformities
* Immediate need for Mechanical Ventilation
* Pregnancy
* Hypercapnic RF
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Modena and Reggio Emilia

OTHER

Sponsor Role lead

Responsible Party

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Alessandro Marchioni

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University Hospital of Modena Policlinico

Modena, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Alessandro Marchioni, MD, PhD

Role: CONTACT

00390594225859

Facility Contacts

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Alessandro Marchioni, MD, PhD

Role: primary

References

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Tonelli R, Cortegiani A, Marchioni A, Fantini R, Tabbi L, Castaniere I, Biagioni E, Busani S, Nani C, Cerbone C, Vermi M, Gozzi F, Bruzzi G, Manicardi L, Pellegrino MR, Beghe B, Girardis M, Pelosi P, Gregoretti C, Ball L, Clini E. Nasal pressure swings as the measure of inspiratory effort in spontaneously breathing patients with de novo acute respiratory failure. Crit Care. 2022 Mar 24;26(1):70. doi: 10.1186/s13054-022-03938-w.

Reference Type DERIVED
PMID: 35331323 (View on PubMed)

Tonelli R, Fantini R, Tabbi L, Castaniere I, Pisani L, Pellegrino MR, Della Casa G, D'Amico R, Girardis M, Nava S, Clini EM, Marchioni A. Early Inspiratory Effort Assessment by Esophageal Manometry Predicts Noninvasive Ventilation Outcome in De Novo Respiratory Failure. A Pilot Study. Am J Respir Crit Care Med. 2020 Aug 15;202(4):558-567. doi: 10.1164/rccm.201912-2512OC.

Reference Type DERIVED
PMID: 32325004 (View on PubMed)

Other Identifiers

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266/16

Identifier Type: OTHER

Identifier Source: secondary_id

UModenaReggio 266/16

Identifier Type: -

Identifier Source: org_study_id

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