Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy
NCT ID: NCT07168213
Last Updated: 2025-09-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
30 participants
INTERVENTIONAL
2025-10-31
2027-12-31
Brief Summary
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Detailed Description
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A total of four 10-minute periods will be performed in randomized order: Nonin 90, Nonin 94, Philips 90, and Philips 94.
At the end of each 10-minute period, arterial gas will be collected through the arterial catheter.
Conditions
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Study Design
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NA
CROSSOVER
TREATMENT
SINGLE
Study Groups
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Nonin oximeter with a 90% SpO2 target
During this periods , oxygen through high flow nasal therapy a will be administered in an manual titration to reach 90% of SpO2.
Manual FiO2 titration with Nonin oximeter (SpO2 target 90%)
FiO2 titration to reach the SpO2 target (set at 90%) with Nonin oximeter
Philips oximeter with a 90% SpO2 target
During this periods , oxygen through high flow nasal therapy a will be administered in an manual titration to reach 90% of SpO2.
Manual FiO2 titration with Philips oximeter (SpO2 target 90%)
FiO2 titration to reach the SpO2 target (set at 90%) with Philips oximeter
Nonin oximeter with a 94% SpO2 target
During this periods , oxygen through high flow nasal therapy a will be administered in an manual titration to reach 94% of SpO2.
Manual FiO2 titration with Nonin oximeter (SpO2 target 94%)
FiO2 titration to reach the SpO2 target (set at 94%) with Nonin oximeter
Philips oximeter with a 94% SpO2 target
During this periods , oxygen through high flow nasal therapy a will be administered in an manual titration to reach 94% of SpO2.
Manual FiO2 titration with Philips oximeter (SpO2 target 94%)
FiO2 titration to reach the SpO2 target (set at 94%) with Philips oximeter
Interventions
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Manual FiO2 titration with Philips oximeter (SpO2 target 90%)
FiO2 titration to reach the SpO2 target (set at 90%) with Philips oximeter
Manual FiO2 titration with Nonin oximeter (SpO2 target 90%)
FiO2 titration to reach the SpO2 target (set at 90%) with Nonin oximeter
Manual FiO2 titration with Philips oximeter (SpO2 target 94%)
FiO2 titration to reach the SpO2 target (set at 94%) with Philips oximeter
Manual FiO2 titration with Nonin oximeter (SpO2 target 94%)
FiO2 titration to reach the SpO2 target (set at 94%) with Nonin oximeter
Eligibility Criteria
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Inclusion Criteria
* Admiitted in intensive care unit
* Presence of an arterial catheter
* Ongoing on high flow nasal oxygen therapy with SpO2 between 88 and 100% with a FiO2 between 40 and 80% with the usual oximeter .
Exclusion Criteria
* False nails or nail polish
* Methemoglobinemia \>0.015 on last available arterial gas
* Patient in isolation (multi-resistant bacteria, C-Difficile, SARS-CoV-2 ...)
* Expected to use another respiratory support within two hour of inclusion (NIV or mechanical ventilation)
18 Years
ALL
No
Sponsors
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Laval University
OTHER
Responsible Party
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François Lellouche
Principal Investigator
Locations
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Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Québec, Quebec, Canada
Countries
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Central Contacts
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Other Identifiers
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2026-4432
Identifier Type: -
Identifier Source: org_study_id
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