Joint Ultrasound Evaluation of Asymptomatic Rheumatic Feet

NCT ID: NCT01677416

Last Updated: 2012-09-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-03-31

Study Completion Date

2012-03-31

Brief Summary

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Objectives: The aims of the present study were to compare ultrasound on asymptomatic feet of patients with rheumatoid arthritis (RA) and normal controls, determine the association between ultrasound and global disease activity, function and goniometric measures in patients with RA and determine the correlation between ultrasound and radiography in the detection of bone erosion.

Methods: The foot joints (talocrural, talocalcaneal, talonavicular, naviculocuneiform, calcaneocuboid, 5th tarsometatarsal and 1st to 5th metatarsophalangeal \[MTP\] joints) of 50 healthy subjects and 50 patients with RA (all with asymptomatic feet) were evaluated bilaterally regarding quantitative/semi-quantitative synovitis, semi-quantitative Power Doppler (PD) signals and erosion using ultrasound. Statistical significance was set to 5%.

Detailed Description

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Conditions

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Rheumatoid Arthritis

Keywords

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Rheumatoid arthritis Ultrasonography Synovitis Foot joints

Study Design

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Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Rheumatoid Arthritis Group

RA with at least one year since diagnosis, asymptomatic feet, and age between 18 and 65 years

No interventions assigned to this group

Control group

Absence of known osteoarticular disease

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Rheumatoid Arthritis Group:

* RA with at least one year since diagnosis
* Asymptomatic feet
* Age between 18 and 65 years Control group
* absence of known osteoarticular disease

Exclusion Criteria

* Peripheral venous insufficiency with retrograde venous flow and/or ochre dermatitis
* Previous surgical intervention and/or fracture in feet/ankles
* Intra-articular corticosteroid injection in previous three months in any of the joints evaluated
* Foot neuropathy
* Pain and swelling in feet or ankles
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Federal University of São Paulo

OTHER

Sponsor Role lead

Responsible Party

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Anamaria Jones

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Rita Furtado, MD

Role: PRINCIPAL_INVESTIGATOR

Federal University of São Paulo

Locations

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Universidade Federal de Sao Paulo

São Paulo, SP - Sao Paulo, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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UNIFESP/2011

Identifier Type: -

Identifier Source: org_study_id