Carpal Bone Erosion in Rheumatoid Arthritis :Diagnostic Value

NCT ID: NCT06562049

Last Updated: 2024-08-20

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 110 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-08-15
• Study Completion Date: 2025-10-01

Brief Summary

Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by proliferative hyper vascularized synovitis which primarily affects synovial joints. Synovium of bursa; tendon sheaths; attachment sites of cartilage, ligament, and tendons to the bone; soft tissue; and bones can be mentioned among the other areas under influence of RA. Changes happen to be symmetrical and may present as fusiform soft tissue swelling, regional osteoporosis, marginal-central erosions, cartilage damage, joint destruction, narrowing of joint space and fibrous ankyloses. Wrist, metacarpophalangeal and metatarsophalangeal joints are the first sites to be affected .Over the past few years, an increasing number of rheumatologists have started to use US in the clinical setting of the early arthritis clinic. While US allows for an accurate and non-invasive multisite assessment of joint involvement in patients with RA, time for US examination is not infinite

Conditions

Rheumatoid Arthritis

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

cases

rheumatoid arthriris patients

musculoskeletal ultrasound

Intervention Type: RADIATION

musculoskeletal ultrasound on both hands

control

systemic lupus patients

musculoskeletal ultrasound

Intervention Type: RADIATION

musculoskeletal ultrasound on both hands

controls

healthy controls

musculoskeletal ultrasound

Intervention Type: RADIATION

musculoskeletal ultrasound on both hands

Interventions

musculoskeletal ultrasound

musculoskeletal ultrasound on both hands

Intervention Type: RADIATION

Eligibility Criteria

Inclusion Criteria

• 1. RA patients fulfilled the 2010 American College of Rheumatoid Arthritis classification criteria.[8] 2. SLE patients fulfilled the 2019 ACR\EULAR classification criteria for SLE.[9] 3. Age above 18 years old. 4. Patient cooperative and can answer questions. 5. Patients who are able and willing to give written informed consent.

Exclusion Criteria

• 1. Age below 18 years and above 60 years. 2. Uncooperative patients. 3. Patient not able and willing to give written informed consent.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sohag University

OTHER

Sponsor Role: lead

Responsible Party

Abeer Abdelaal Aly

resident of Physical medicine, Rheumatology and Rehabilitation Department

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Sohag University hospitals

Sohag, , Egypt

Countries

Egypt

Central Contacts

abeer A abdelaal, Resident

Role: CONTACT

abeer_abdelaal_post@med.sohag.edu.eg

01206290115

ahmed M mahrous, Professor

Role: CONTACT

Facility Contacts

Magdy Amin, Professor

Role: primary

References

Sommer OJ, Kladosek A, Weiler V, Czembirek H, Boeck M, Stiskal M. Rheumatoid arthritis: a practical guide to state-of-the-art imaging, image interpretation, and clinical implications. Radiographics. 2005 Mar-Apr;25(2):381-98. doi: 10.1148/rg.252045111.

Reference Type: BACKGROUND

PMID: 15798057 (View on PubMed)

Ejbjerg BJ, Vestergaard A, Jacobsen S, Thomsen H, Ostergaard M. Conventional radiography requires a MRI-estimated bone volume loss of 20% to 30% to allow certain detection of bone erosions in rheumatoid arthritis metacarpophalangeal joints. Arthritis Res Ther. 2006;8(3):R59. doi: 10.1186/ar1919. Epub 2006 Mar 15.

Reference Type: BACKGROUND

PMID: 16542505 (View on PubMed)

Mottonen TT. Prediction of erosiveness and rate of development of new erosions in early rheumatoid arthritis. Ann Rheum Dis. 1988 Aug;47(8):648-53. doi: 10.1136/ard.47.8.648.

Reference Type: BACKGROUND

PMID: 3137902 (View on PubMed)

Other Identifiers

soh-med-24-07-10MS

Identifier Type: -

Identifier Source: org_study_id