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Ultrasound Evaluation of Hands in Patients With Systemic Lupus Erythematosus

NCT ID: NCT01471301

Last Updated: 2011-11-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-06-30

Brief Summary

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The purpose of this study is to evaluate ultrasound hands in patients with systemic lupus erythematosus.

Detailed Description

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Introduction: The systemic lupus erythematosus (SLE) is a disease with a common articular involvement. Approximately 1-2% of patients with SLE have joint inflammation similar to rheumatoid arthritis (RA). There are no well-designed studies of lupus arthropathy.

Primary objectives: To evaluate the ultrasonographic examination of the hands in patients with systemic lupus erythematosus and make its correlation with examination of patients with rheumatoid arthritis (RA) established and with clinical, serological, radiological and functional.

Material and methods: a transversal study will be carried out on patients diagnosed with with SLE and RA.

Clinical Instruments: count of swollen and tender joints, visual analogue scale (VAS) for pain (0-10 cm), edema and for disease activity; disease activity (DAS 28 and SLEDAI), hand grip strength and pinch (Jamar dynamometer and Preston Pinch Gauge); functional questionnaires (HAQ and DASH). It will be observed the presence of "puffy hands", Raynaud's phenomenon and presence of autoantibodies.

Radiographic instruments: evaluation of radiographs of hands and wrists according to the Sharp score modified by van der Heijde. Ultrasonographic Instruments (quantitative and semi-quantitative measures): synovial hyperplasia, synovial blood flow (Power Doppler), bone erosions and cartilage. The joints that will be evaluated: radiocarpal, distal radioulnar, first to fifth metacarpophalangeal and proximal interphalangeal. Ultrasonographic interobserver reproducibility will be carried out in 10% of the patients. All the examinators will be blind for each other findings. Rheumatoid factor and anti-CCP will be investigated in RA patients. Statistical significance will be set at 5%.

Conditions

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Lupus Erythematosus, Systemic Arthritis, Rheumatoid

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* age between 18 and 60 years;
* female and male;
* patients with SLE, according to the revised classification criteria of the ACR (Arthritis Rheum, 1997) with current or previous joint activity (arthritis or arthralgia;
* patients with established RA according to ACR classification criteria (Arthritis Rheum, 1988)

Exclusion Criteria

* changing the dose or drug-based immunosuppression in the last 3 months.
* corticosteroid pulse therapy in the last 30 days;
* infiltration with corticosteroids at hand in the last 3 months;
* previous surgery in the joints studied;
* irreducible deformity of the joints studied;
* overlap with other joint diseases or collagen;
* chiropractic diabetic;
* hypothyroidism
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Federal University of São Paulo

OTHER

Sponsor Role lead

Responsible Party

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Ana Leticia Pirozzi Buosi

Ultrasound evaluation of hands in patients with Systemic Lupus Erythematosus

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ana Letícia Pirozzi Buosi

Role: PRINCIPAL_INVESTIGATOR

Outros

Locations

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Unifesp

São Paulo, São Paulo, Brazil

Site Status RECRUITING

Countries

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Brazil

Central Contacts

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Ana Leticia Pirozzi Buosi

Role: CONTACT

[email protected]
551181352131

Facility Contacts

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Ana Leticia Piirozzi Buosi

Role: primary

551181352131

Other Identifiers

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ABuosi

Identifier Type: -

Identifier Source: org_study_id