Measurement of Eye Blood Flow and Renal Function in Healthy and Diabetic Patients
NCT ID: NCT01626469
Last Updated: 2019-08-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE1/PHASE2
24 participants
INTERVENTIONAL
2012-05-31
2020-09-30
Brief Summary
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Detailed Description
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We hypothesize that salt intake will affect OA blood flow.
We will initially look at both eye and renal response to subjects on a low salt diet (10mEq Na/day) followed by response to high salt diet (200mEq Na/day). In addition, we may look at eye response while subjects consume their regular diet.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Arm A
Captopril 25 mg (Admission 1, Day 1, low salt diet) Matched Placebo (Admission 1, Day 2, low salt diet) Captopril 25 mg (Admission 2, Day 1, high salt diet) Matched Placebo (Admission 2, Day 2, high salt diet)
Captopril
25mg Captopril
placebo
placebo
Captopril
Matched Placebo (Admission 1, Day 1, low salt diet) Captopril 25 mg (Admission 1, Day 2, low salt diet) Matched Placebo (Admission 2, Day 1, high salt diet) Captopril 25 mg (Admission 2, Day 2, high salt diet)
Captopril
25mg Captopril
placebo
placebo
Interventions
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Captopril
25mg Captopril
placebo
placebo
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Heart Attack or Stroke within the last 6 months
* Pregnant or lactating females
18 Years
75 Years
ALL
No
Sponsors
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Brigham and Women's Hospital
OTHER
Responsible Party
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Norman K. Hollenberg, MD, PhD
Director of Physiologic Research Division, Department of Radiology
Principal Investigators
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Norman K Hollenberg, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Brigham and Women's Hospital
Ebrahim Barkoudah, M.D.,M.P.H.
Role: STUDY_DIRECTOR
Brigham and Women's Hospital
Locations
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Brigham and Women's Hospital
Boston, Massachusetts, United States
Countries
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Central Contacts
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Other Identifiers
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2011P002805
Identifier Type: -
Identifier Source: org_study_id
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