Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning in Patients With Type 1 Diabetes

NCT ID: NCT03906383

Last Updated: 2019-04-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-11-21

Study Completion Date

2018-10-16

Brief Summary

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Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury. It remains unknown whether this can be used in retinal ischemic diseases. The purpose of the present study is to examine if the autoregulation of retinal vessel diameters in diabetic patients change after remote ischemic conditioning and if the observations are different from what have been observed in normal persons.

Detailed Description

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Conditions

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Retinal Ischemia Diabetes Complications Ischemia Diabetes Mellitus, Type 1

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Remote Ischemic Conditioning

Group Type EXPERIMENTAL

Remote Ischemic Conditioning

Intervention Type OTHER

Brief reversible restriction of blood flow to upper limb in four cycles of 5 minutes of inflation at 200mm Hg followed by 5 minutes of deflation.

Interventions

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Remote Ischemic Conditioning

Brief reversible restriction of blood flow to upper limb in four cycles of 5 minutes of inflation at 200mm Hg followed by 5 minutes of deflation.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diabetes type 1
* Diabetic retinopathy

Exclusion Criteria

* Previous treatment for diabetic retinopathy
* Other ocular and systemic diseases requiring treatment
* Pregnancy or lactation
Minimum Eligible Age

20 Years

Maximum Eligible Age

31 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Aarhus

Aarhus C, Danmark, Denmark

Site Status

Countries

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Denmark

References

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El Dabagh Y, Petersen L, Pedersen M, Bek T. Reduced baseline diameter and contraction of peripheral retinal arterioles immediately after remote ischemia in diabetic patients. Graefes Arch Clin Exp Ophthalmol. 2019 Oct;257(10):2095-2101. doi: 10.1007/s00417-019-04407-x. Epub 2019 Jul 4.

Reference Type DERIVED
PMID: 31273510 (View on PubMed)

Other Identifiers

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RIK_RVA Diabetes

Identifier Type: -

Identifier Source: org_study_id

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