Coronary Flow Reserve and Glucometabolic State

NCT ID: NCT00845468

Last Updated: 2009-02-18

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 190 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2006-01-31

Brief Summary

Diabetes mellitus is a major risk factor for the development of ischemic heart disease, and patients with diabetes mellitus have a worse outcome following an acute myocardial infarction than non-diabetic patients. Furthermore, abnormal glucose metabolism below the diagnostic threshold of diabetes mellitus is also associated with increased risk of death compared to patients with a normal glucose metabolism. The frequency of abnormal glucose metabolism in acute myocardial infarction is high, and approximately 70% of myocardial infarction patients have diabetes mellitus, newly diagnosed diabetes mellitus or impaired glucose tolerance, leaving only 30% with normal glucose metabolism. The increased mortality among patients with acute myocardial infarction and abnormal glucose metabolism seems mainly related to a higher occurrence of congestive heart failure, suggesting that an abnormal glucose metabolism may play an important role among others in endothelial dysfunction, infarct healing and overall left ventricle function. This raises the question, whether patients with acute myocardial infarction and abnormal glucose metabolism have increased frequency of micro- or macrovascular disease or both.

Coronary flow velocity reserve reflects the patency of the epicardial coronary artery in combination with vasodilator capacity of the microcirculation and may therefore offer a tool for assessment of macro- and microcirculation.

This study will focus on the relation between coronary flow velocity reserve estimated by transthoracal Doppler echocardiography and mortality, risk for heart failure and left ventricle function after acute myocardial infarction stratified according to glycometabolic state

Conditions

Acute Myocardial Infarction; Diabetes Mellitus; Prediabetes

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

No treatment

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

1. Newly diagnosed first AMI based on characteristic clinical symptoms and/or electrocardiographic signs of AMI and Troponin T or I or CK-MB over diagnostic limits for AMI

2. Referral for coronary arteriography based on the actual myocardial infarction

3. Written informed consent

Exclusion Criteria

1. Previous myocardial infarction

2. Asthma bronchiale

3. 2 or/and 3 degree atrio-ventricular block and paced rhythm

4. Mental state that makes the patient unavailable in attending the study

5. Use of dipyridamol

6. Sick Sinus Syndrome

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Medicinsk Forsknings Afdeling

OTHER

Sponsor Role: lead

Responsible Party

Medicinsk Forskning Afdeling

Principal Investigators

Brian B Løgstrup, MD

Role: PRINCIPAL_INVESTIGATOR

Medicinsk Forsknings Afdeling

Locations

Hospital of Fünen Svendborg

Svendborg, Svendborg, Denmark

Countries

Denmark

References

Logstrup BB, Hofsten DE, Christophersen TB, Moller JE, Botker HE, Pellikka PA, Egstrup K. Influence of abnormal glucose metabolism on coronary microvascular function after a recent myocardial infarction. JACC Cardiovasc Imaging. 2009 Oct;2(10):1159-66. doi: 10.1016/j.jcmg.2009.06.012.

Reference Type: DERIVED

PMID: 19833304 (View on PubMed)

Other Identifiers

VF 20050103

Identifier Type: -

Identifier Source: secondary_id

07-4-B368-A1392-22379

Identifier Type: -

Identifier Source: org_study_id