Study of the Relationship Between Blood Vessels and Insulin Response in Adolescents
NCT ID: NCT00374361
Last Updated: 2016-06-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
66 participants
OBSERVATIONAL
2003-07-31
2006-06-30
Brief Summary
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Detailed Description
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Healthy adolescents between 8 and 18 years of age are being studied in the Ohio State University General Clinical Research Center. Two visits will be necessary. One will be a screening visit to determine the child's stage of puberty and obtain a medical history. The second will be the study visit. During the latter, blood vessel function will be determined by studying the change in forearm blood flow before and after blood flow to the forearm is stopped. Insulin sensitivity will be determined using glucose water given into a vein.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Caucasian Adolescents
Caucasian Adolescents
No interventions assigned to this group
African-American Adolescents
African-American Adolescents
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Between 8 and 18 years of age
Exclusion Criteria
* Chronic Disease
* Acute Disease
* Medication Requirement
8 Years
18 Years
ALL
Yes
Sponsors
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Nationwide Children's Hospital
OTHER
Ohio State University
OTHER
Responsible Party
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Robert Hoffman
Professor
Principal Investigators
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Robert P Hoffman, MD
Role: STUDY_CHAIR
Ohio State University
Locations
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Ohio State University
Columbus, Ohio, United States
Countries
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References
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Hoffman RP. Indices of insulin action calculated from fasting glucose and insulin reflect hepatic, not peripheral, insulin sensitivity in African-American and Caucasian adolescents. Pediatr Diabetes. 2008 Jun;9(3 Pt 2):57-61. doi: 10.1111/j.1399-5448.2007.00350.x. Epub 2008 Jan 21.
Duck MM, Hoffman RP. Impaired endothelial function in healthy African-American adolescents compared with Caucasians. J Pediatr. 2007 Apr;150(4):400-6. doi: 10.1016/j.jpeds.2006.12.034.
Hoffman RP. Increased fasting triglyceride levels are associated with hepatic insulin resistance in Caucasian but not African-American adolescents. Diabetes Care. 2006 Jun;29(6):1402-4. doi: 10.2337/dc06-2460. No abstract available.
Xie L, Hoffman RP, Veng-Pedersen P. Noncompartmental pharmacokinetics analysis of glucose-stimulated insulin response in African-American and Caucasian youths. Biopharm Drug Dispos. 2009 Apr;30(3):117-25. doi: 10.1002/bdd.652.
Other Identifiers
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AHA 0355195B
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
ENDO 203
Identifier Type: -
Identifier Source: org_study_id
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