Type 1 Diabetes Autonomic and Vascular Function

NCT ID: NCT06786546

Last Updated: 2025-09-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

72 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-08-07

Study Completion Date

2029-12-31

Brief Summary

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The goal of this clinical trial is to investigate the autonomic and vascular function in men and women with Type 1 diabetes. The main questions it aims to answer are:

1. Patients with type 1 diabetes exhibit attenuated vascular function during steady-state exercise
2. Patients with type 1 diabetes have altered autonomic function at rest and during exercise pressor reflex
3. Patients with type 1 diabetes have attenuated muscle sympathetic activity

Detailed Description

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Elevated blood glucose levels in individuals with type 1 diabetes can result in both microvascular and macrovascular complications. Research conducted by Song et al. revealed that children with type 1 diabetes exhibit abnormal cerebral perfusion. Additionally, autonomic mechanisms are affected in type 1 diabetes, as indicated in an animal study which demonstrated that the exercise pressor reflex is exaggerated in both male and female rats during the early stages of the disease. However, whether this also occurs in human patients with type 1 diabetes remains unknown.

Therefore, in this study we are interested in studying the autonomic control of exercise and vascular function in T1DM humans.

Conditions

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Type 1 Diabetes (Juvenile Onset) Type 1 Diabetes Diabetes, Autoimmune

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Type 1 Diabetes Group

Men and women diagnosed with Type 1 diabetes

No interventions assigned to this group

Healthy Control group

Healthy men and women will be recruited, matched to the Type 1 diabetes group for age, sex and weight

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Type 1 diabetes or a Healthy control

Exclusion Criteria

* BMI \> 40kg/m2
* Cancer with current treatment
* HIV
* Smoker cigarettes
* Are pregnant or breastfeeding
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Dell Medical School at The University of Texas at Austin

UNKNOWN

Sponsor Role collaborator

University of Texas at Austin

OTHER

Sponsor Role lead

Responsible Party

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Jasdeep Kaur

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Texas at Austin

Austin, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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STUDY00004548

Identifier Type: -

Identifier Source: org_study_id

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