Vascular Reactivity in Metabolic Syndrome and Diabetic Patients Using Diffuse Optical Spectroscopy

NCT ID: NCT00793481

Last Updated: 2022-11-01

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2008-11-30
• Study Completion Date: 2013-11-30

Brief Summary

Metabolic Syndrome is a highly prevalent condition that is comprised of several major clustering factors that increase the risk for developing cardiovascular disease. Diffuse Optical Spectroscopy is a non-invasively measure can show changes in the microvasculature of human. Diffuse Optical Spectroscopy measures the optical absorption and scattering properties of near-infrared light in tissues such as muscle in order to quantify the absolute concentration of oxygenated and deoxygenated hemoglobin, water, and lipids. It provides quantitative and functional information on the microvasculature related to tissue perfusion, metabolic changes, and indicators of tissue damage.

Detailed Description

The researchers can use Diffuse Optical Spectroscopy to monitor changes in the microvasculature of patients with Metabolic Syndrome and diabetic mellitus, and patients with Diabetic Peripheral and Autonomic Neuropathy, versus non-diseased and predisposed subjects by evaluating the changes in oxygen metabolism. The Diffuse Optical Spectroscopy measure the changes in the concentration and oxygen saturation of hemoglobin in the microvasculature under stress, for example, during exercise and in response to changes in breathing habits. The sensitivity of Diffuse Optical Spectroscopy to tissue hemodynamics provides an impressive arena of useful clinical applications..

Conditions

Diabetes Mellitus

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

Diagnostic tool

Diffuse Optical Spectroscopy non-invasively measure changes in the microvasculature

Diffuse Optical Spectroscopy

Intervention Type: DEVICE

Diffuse Optical Spectroscopy non-invasively measure changes in the microvasculature

Interventions

Diffuse Optical Spectroscopy

Diffuse Optical Spectroscopy non-invasively measure changes in the microvasculature

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Adult ages of 45 to 75
• Have been clinically diagnosed with Type II Diabetes Mellitus
• Have a diagnosis of Metabolic Syndrome

Exclusion Criteria

• taking light-sensitive drugs for use in photodynamic therapy
• pregnant

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Beckman Laser Institute University of California Irvine

OTHER

Sponsor Role: collaborator

University of California, Irvine

OTHER

Sponsor Role: lead

Responsible Party

Beckman Laser Institute and Medical Center

Ping Wang, M.D., Professor of Medicine

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ping H Wang, M.D.

Role: PRINCIPAL_INVESTIGATOR

Joslin Diabetes Center,UCI

Bruce Tromberg, PhD

Role: STUDY_DIRECTOR

Beckman Laser Institute

Locations

Beckman Laser Institute Medical clinic

Irvine, California, United States

Countries

United States

Other Identifiers

20086415

Identifier Type: -

Identifier Source: org_study_id