Microvascular Reactivity.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-06-30

Study Completion Date

2005-09-30

Brief Summary

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This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).

Detailed Description

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Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.

Conditions

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Diabetes Retinopathy Vascular Pathology

Keywords

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endothelium iontophoresis acetylcholine nitroglycerin vasodilation

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

OTHER

Interventions

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Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin

Intervention Type DEVICE

Eligibility Criteria

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Exclusion Criteria

\-

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Principal Investigators

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David G Silverman

Role: PRINCIPAL_INVESTIGATOR

Yale University

Locations

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Yale School of Medicine

New Haven, Connecticut, United States

Site Status

Countries

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United States

References

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Schonberger RB, Worden WS, Shahmohammadi K, Menn K, Silverman TJ, Stout RG, Shelley KH, Silverman DG. Topical non-iontophoretic application of acetylcholine and nitroglycerin via a translucent patch: a new means for assessing microvascular reactivity. Yale J Biol Med. 2006 Mar;79(1):1-7.

Reference Type DERIVED

PMID: 17876370 (View on PubMed)

Other Identifiers

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HIC-12397-1

Identifier Type: -

Identifier Source: org_study_id