Study on Tear Proteins in Diabetic Retinopathy of Type 2 Diabetics

NCT ID: NCT00698698

Last Updated: 2009-02-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

350 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-01-31

Study Completion Date

2011-06-30

Brief Summary

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Diabetes mellitus is becoming a global epidemic. There is a need to devise a non invasive method for detection of diabetes and its related complication. Tear proteins are easy to collect causing no harm to a patient and different studies indicate that tear proteins of diabetic patients are significantly different from non diabetic population. This difference in the composition of tear proteins become more pronounced with advancement of diabetic retinopathy.

Detailed Description

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Diabetes mellitus causes a significant alteration in tear proteins. If we analyze tear proteins by means of electrophoresis, HPLC, and mass spectroscopy.

We can find different type of tear proteins in different grades of diabetic retinopathy these biomarkers can help in mass screening , diagnosis and management of diabetic population.

Conditions

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Diabetes Mellitus

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Non diabetic

Normal age and sex matched population

No interventions assigned to this group

Grade 1

Diabetic population with no retinopathy or Mild non proliferative diabetic retinopathy

No interventions assigned to this group

Grade 2

Moderate non proliferative diabetic retinopathy

No interventions assigned to this group

Grade 3

Severe non proliferative diabetic retinopathy

No interventions assigned to this group

Grade 4

Proliferative diabetic retinopathy and advanced diabetic eye disease

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* diabetic patients with type 2 diabetes
* age above 30
* willing to participate

Exclusion Criteria

* ocular surface disorders.
* collagen vascular diseases
* Limbal hyperemia
* previous ocular surgery
* creatinine level above 1.0
* liver diseases
Minimum Eligible Age

30 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Dow University of Health Sciences

OTHER

Sponsor Role lead

Responsible Party

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Dow university of Health Sciences Karachi Pakistan

Principal Investigators

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Dr. Jamshed Ahmed, FCPS

Role: PRINCIPAL_INVESTIGATOR

Dow University of Health Sciences Pakistan

Locations

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Dow University of Health Sciences

Karachi, Sindh, Pakistan

Site Status

Countries

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Pakistan

Other Identifiers

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Tear proteins

Identifier Type: -

Identifier Source: org_study_id

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