Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation

NCT ID: NCT01558505

Last Updated: 2013-01-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

142 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-30

Brief Summary

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Drug-eluting balloon showed positive results in terms of restenosis reduction in peripheral intervention (PTA). The aim of the study is to investigate in a randomized fashion the efficacy and safety of Paclitaxel-eluting balloon (PEB) (In.Pact Amphirion, Invatec, Brescia, Italy) versus non drug-eluting balloon (NEB) (Amphirion deep, Invatec, Brescia, Italy) in diabetic patients with Critical Limb Ischemia (CLI) undergoing PTA of below-the-knee (BTK) vessels.

Detailed Description

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Conditions

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Critical Limb Ischemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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standard PTA

conventional balloon angioplasty

Group Type ACTIVE_COMPARATOR

POBA

Intervention Type DEVICE

conventional balloon angioplasty

Drug-eluting balloon angioplasty

paclitaxel-eluting balloon angioplasty

Group Type EXPERIMENTAL

PEB

Intervention Type DEVICE

paclitaxel-eluting balloon angioplasty

Interventions

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PEB

paclitaxel-eluting balloon angioplasty

Intervention Type DEVICE

POBA

conventional balloon angioplasty

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* age\>18 years
* angiographic stenosis\>50% or occlusion of one below-knee vessel

Exclusion Criteria

* allergy to Paclitaxel
* contraindication for combined antiplatelet treatment
* life expectancy \<1 year
* hypersensitivity or contraindication to one of the study drugs
* lack of consent
* need for amputation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Leonardo Bolognese, MD

OTHER

Sponsor Role lead

Responsible Party

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Leonardo Bolognese, MD

Director

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Cardiovascular Department, Ospedale S.Donato

Arezzo, AR, Italy

Site Status

Countries

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Italy

References

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Liistro F, Porto I, Angioli P, Grotti S, Ricci L, Ducci K, Falsini G, Ventoruzzo G, Turini F, Bellandi G, Bolognese L. Drug-eluting balloon in peripheral intervention for below the knee angioplasty evaluation (DEBATE-BTK): a randomized trial in diabetic patients with critical limb ischemia. Circulation. 2013 Aug 6;128(6):615-21. doi: 10.1161/CIRCULATIONAHA.113.001811.

Reference Type DERIVED
PMID: 23797811 (View on PubMed)

Other Identifiers

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Arezzo005

Identifier Type: -

Identifier Source: org_study_id

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