Drug Eluting Balloon in peripherAl inTErvention SFA

NCT ID: NCT01556542

Last Updated: 2013-01-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

104 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-30

Brief Summary

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The purpose of this study is to evaluate the efficacy of drug-eluting balloon angioplasty followed by nitinol stent implantation versus nitinol stent implantation in superficial femoral artery and popliteal artery stenosis.

Detailed Description

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Conditions

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Peripheral Arterial Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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standard PTA

nitinol stent implantation

Group Type ACTIVE_COMPARATOR

nitinol stent implantation

Intervention Type DEVICE

nitinol stent implantation

DEB

paclitaxel-eluting balloon angioplasty followed by nitinol stent implantation

Group Type EXPERIMENTAL

paclitaxel-eluting balloon angioplasty followed by nitinol stent implantation

Intervention Type DEVICE

paclitaxel-eluting balloon angioplasty followed by nitinol stent implantation

Interventions

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paclitaxel-eluting balloon angioplasty followed by nitinol stent implantation

paclitaxel-eluting balloon angioplasty followed by nitinol stent implantation

Intervention Type DEVICE

nitinol stent implantation

nitinol stent implantation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* age\>18 years
* intermittent claudication(Fontane III or IV)
* angiographic stenosis\>50% or occlusion of superficial femoral-popliteal artery\>40mm
* at least one below-knee vessel to the ankle

Exclusion Criteria

* allergy to Paclitaxel
* contraindication for combined antiplatelet treatment
* life expectancy \<1 year
* hypersensitivity or contraindication to one of the study drugs
* lack of consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Leonardo Bolognese, MD

OTHER

Sponsor Role lead

Responsible Party

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Leonardo Bolognese, MD

Director of Cardiovascular Department

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Francesco Liistro, MD

Role: PRINCIPAL_INVESTIGATOR

Cardiovascular Department, San Donato Hospital, Arezzo, Italy

Locations

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Cardiovascular Department, Ospedale S.Donato

Arezzo, AR, Italy

Site Status

Countries

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Italy

References

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Liistro F, Grotti S, Porto I, Angioli P, Ricci L, Ducci K, Falsini G, Ventoruzzo G, Turini F, Bellandi G, Bolognese L. Drug-eluting balloon in peripheral intervention for the superficial femoral artery: the DEBATE-SFA randomized trial (drug eluting balloon in peripheral intervention for the superficial femoral artery). JACC Cardiovasc Interv. 2013 Dec;6(12):1295-302. doi: 10.1016/j.jcin.2013.07.010. Epub 2013 Nov 13.

Reference Type DERIVED
PMID: 24239203 (View on PubMed)

Other Identifiers

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Arezzo004

Identifier Type: -

Identifier Source: org_study_id

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