Stenting of the Superficial Femoral and/or Proximal Popliteal Artery Project

NCT ID: NCT01820637

Last Updated: 2019-03-22

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

57 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-08-23

Study Completion Date

2017-02-20

Brief Summary

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To determine whether the Boston Scientific nitinol drug-eluting stent shows acceptable performance at 9 months when treating Superficial Femoral (SFA) and/or Proximal Popliteal Artery (PPA) lesions.

Detailed Description

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Conditions

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Atherosclerosis of Native Arteries of the Extremities

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Test device arm (DES SFA)

Patients in this arm will receive the study device: the Boston Scientific DES SFA Paclitaxel-Eluting Self-Expanding Stent System (DES SFA)

Group Type EXPERIMENTAL

The Boston Scientific DES SFA Paclitaxel-Eluting Self-Expanding Stent System (DES SFA)

Intervention Type DEVICE

Drug-eluting SFA self-expanding stent

Interventions

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The Boston Scientific DES SFA Paclitaxel-Eluting Self-Expanding Stent System (DES SFA)

Drug-eluting SFA self-expanding stent

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subjects age 18 and older
* Subject (or Legal Guardian if applicable) has signed the consent form and is willing and able to provide consent before any study-specific tests or procedures are performed and agrees to attend all required follow-up visits
* Chronic, symptomatic lower limb ischemia defined as Rutherford categories 2, 3 or 4
* Stenotic, restenotic (from angioplasty only, previous treatment with drug coated balloon is not allowed) or occlusive lesion(s) located in the native superficial femoral artery or proximal popliteal artery:

1. Degree of stenosis ≥70% by visual angiographic assessment
2. Vessel diameter ≥ 4 and ≤ 6mm
3. Total lesion length (or series of lesions) ≥30 mm and ≤110 mm

* (Note: tandem lesions may be treated, provided that the tandem lesion segment can be covered with only one stent)
4. Target lesion located at least three centimeters above the inferior edge of the femur
* Patent infrapopliteal and popliteal artery, i.e., single vessel runoff or better with at least one of three vessels patent (\<50% stenosis) to the ankle or foot
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Stefan Müller-Hülsbeck, Prof.

Role: PRINCIPAL_INVESTIGATOR

Ev. Luth. Diakonissenanstalt Flensburg

Locations

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Royal Prince Alfred Hospital

Camperdown, , Australia

Site Status

Prince of Wales Hospital

Randwick, , Australia

Site Status

Allgemeines Krankenhaus AKH

Vienna, Austria, , Austria

Site Status

AZ Sint-Blasius

Dendermonde, , Belgium

Site Status

Ziekenhuis Oost Limburg

Genk, , Belgium

Site Status

Regionaal Ziekenhuis Heilig Hart Tienen

Tienen, , Belgium

Site Status

Universitäts-Herzzentrum Freiburg Bad Krozingen GmbH

Bad Krozingen, , Germany

Site Status

Ev. Luth. Diakonissenanstalt Flensburg

Flensburg, , Germany

Site Status

Universitätsklinikum Heidelberg

Heidelberg, , Germany

Site Status

Universität Leipzig

Leipzig, , Germany

Site Status

Auckland City Hospital

Auckland, , New Zealand

Site Status

Braemar Hospital

Hamilton, , New Zealand

Site Status

Middlemore Hospital

Otahuhu, , New Zealand

Site Status

Countries

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Australia Austria Belgium Germany New Zealand

References

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Dake MD, Ansel GM, Jaff MR, Ohki T, Saxon RR, Smouse HB, Zeller T, Roubin GS, Burket MW, Khatib Y, Snyder SA, Ragheb AO, White JK, Machan LS; Zilver PTX Investigators. Paclitaxel-eluting stents show superiority to balloon angioplasty and bare metal stents in femoropopliteal disease: twelve-month Zilver PTX randomized study results. Circ Cardiovasc Interv. 2011 Oct 1;4(5):495-504. doi: 10.1161/CIRCINTERVENTIONS.111.962324. Epub 2011 Sep 27.

Reference Type BACKGROUND
PMID: 21953370 (View on PubMed)

Muller-Hulsbeck S, Keirse K, Zeller T, Schroe H, Diaz-Cartelle J. Twelve-Month Results From the MAJESTIC Trial of the Eluvia Paclitaxel-Eluting Stent for Treatment of Obstructive Femoropopliteal Disease. J Endovasc Ther. 2016 Oct;23(5):701-7. doi: 10.1177/1526602816650206. Epub 2016 May 18.

Reference Type DERIVED
PMID: 27193308 (View on PubMed)

Other Identifiers

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S2049

Identifier Type: -

Identifier Source: org_study_id

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