Drug Eluting Balloon in Peripheral Intervention for In-Stent Restenosis

NCT ID: NCT01558531

Last Updated: 2015-02-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Total Enrollment

44 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-31

Brief Summary

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The purpose of this study is to evaluate the efficacy of drug-eluting balloon angioplasty followed versus conventional balloon angioplasty in superficial femoral artery and popliteal artery re-stenosis.

Detailed Description

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Conditions

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Peripheral Arterial Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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DEB

paclitaxel-eluting balloon angioplasty

DEB

Intervention Type DEVICE

paclitaxel-eluting balloon angioplasty

conventional PTA

historical conventional balloon angioplasty control group (patients referred to our institution between 2008 and 2009)

POBA

Intervention Type DEVICE

conventional balloon angioplasty

Interventions

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DEB

paclitaxel-eluting balloon angioplasty

Intervention Type DEVICE

POBA

conventional balloon angioplasty

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* age\>18 years
* intermittent claudication (Fontane III or IV)
* angiographic stenosis\>50% or occlusion of superficial femoral-popliteal artery\>40mm, previously treated with nitinol stent implantation, with at least one below-knee vessel to the ankle

Exclusion Criteria

* allergy to Paclitaxel
* contraindication for combined antiplatelet treatment
* life expectancy \<1 year
* hypersensitivity or contraindication to one of the study drugs
* lack of consent
* need for amputation
* angiographic evidence of stent fracture
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Leonardo Bolognese, MD

OTHER

Sponsor Role lead

Responsible Party

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Leonardo Bolognese, MD

Director

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Cardiovascular Department, Ospedale S.Donato

Arezzo, AR, Italy

Site Status

Countries

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Italy

References

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Grotti S, Liistro F, Angioli P, Ducci K, Falsini G, Porto I, Ricci L, Ventoruzzo G, Turini F, Bellandi G, Bolognese L. Paclitaxel-Eluting Balloon vs Standard Angioplasty to Reduce Restenosis in Diabetic Patients With In-Stent Restenosis of the Superficial Femoral and Proximal Popliteal Arteries: Three-Year Results of the DEBATE-ISR Study. J Endovasc Ther. 2016 Feb;23(1):52-7. doi: 10.1177/1526602815614555. Epub 2015 Oct 28.

Reference Type DERIVED
PMID: 26511896 (View on PubMed)

Liistro F, Angioli P, Porto I, Ricci L, Ducci K, Grotti S, Falsini G, Ventoruzzo G, Turini F, Bellandi G, Bolognese L. Paclitaxel-eluting balloon vs. standard angioplasty to reduce recurrent restenosis in diabetic patients with in-stent restenosis of the superficial femoral and proximal popliteal arteries: the DEBATE-ISR study. J Endovasc Ther. 2014 Feb;21(1):1-8. doi: 10.1583/13-4420R.1.

Reference Type DERIVED
PMID: 24502477 (View on PubMed)

Other Identifiers

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Arezzo006

Identifier Type: -

Identifier Source: org_study_id

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