DEB ( Drug Eluting Balloon) in Crural Arteries and Critical Limb Ischemia

NCT ID: NCT02750605

Last Updated: 2022-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-02-29

Study Completion Date

2022-08-30

Brief Summary

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The purpose of this trial is to compare short- medium long-term results in treatment of PAD (peripheral arterial disease) in the crural arteries with either drug coated balloon or conventional balloons in a prospective , randomized, single center study

Results will be defined as:

Limb salvage, Event-free survival, Freedom from TLR (target lesion revascularization), Primary patency, Clinical success, Serious adverse events, and the patients will be followed-up for 1 years.

Primary endpoints:

Primary Patency at 12 months, TLR (clinical driven),

Secondary endpoints:

Event free survival, Clinical success at 6,12 months, Technical success, Serious adverse events,

Detailed Description

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Conditions

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Peripheral Vascular Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Drug eluting balloon angioplasty

Intervention with DEB angioplasty in long lesions of crural arteries

Group Type EXPERIMENTAL

DEB

Intervention Type DEVICE

Intervention with drug eluting balloon.

Plain old balloon angioplasty

Intervention with plain old balloon angioplasty POBA in long lesions of crural arteries

Group Type ACTIVE_COMPARATOR

POBA

Intervention Type DEVICE

Intervention with old technology as comparison

Interventions

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DEB

Intervention with drug eluting balloon.

Intervention Type DEVICE

POBA

Intervention with old technology as comparison

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Critical limb ischemia. Rutherford class 4-6
* Crural disease, long lesions, more than 2 cm.
* Life expectancy \> 1year
* \> 18 years

Exclusion Criteria

* Pregnancy
* Patients disapproval
* Allergy to drug or contrast
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Skane University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Torbjorn Fransson

Consultant, Vascular Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Torbjörn Fransson

Role: PRINCIPAL_INVESTIGATOR

SUS, Malmö

Locations

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Vascular center

Malmo, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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TF3

Identifier Type: -

Identifier Source: org_study_id