Drug-eluting Balloon vs. Conventional Balloon in the Treatment of (re)Stenosis - a Randomized Prospective Study

NCT ID: NCT03023098

Last Updated: 2017-01-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

57 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2016-11-30

Brief Summary

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The purpose of this study is to determine whether the use of drug-eluting balloons is effective in the treatment of (re)stenosis in bypass vein grafts.

Detailed Description

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Drug-eluting devices have proved beneficial in the treatment of stenosis in native coronary and lower limb arteries. Stenosis and restenosis is a known problem in bypass vein grafts, and drug-eluting devices might be beneficial in this field as well.

In the procedure a conventional balloon is passed through the stenosis which is then dilated. After this patients are randomized before a second dilatation with either a conventional balloon or a drug-coated balloon.

The stenosis is evaluated preoperatively and followed up by means of ultrasound by a vascular technician. Follow-up will end at 12 months.

Conditions

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Peripheral Artery Occlusive Disease Peripheral Artery Restenosis Peripheral Artery Stenosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Drug-eluting balloon

Group Type EXPERIMENTAL

Drug-eluting balloon

Intervention Type DEVICE

After passing the stenosis it is dilated with a conventional balloon. The patient is randomized to a second dilatation with a drug-eluting balloon

Conventional PTA

Group Type ACTIVE_COMPARATOR

Conventional PTA

Intervention Type DEVICE

After passing the stenosis it is dilated with a conventional balloon. The patient is randomized to a second dilatation with a conventional balloon

Interventions

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Conventional PTA

After passing the stenosis it is dilated with a conventional balloon. The patient is randomized to a second dilatation with a conventional balloon

Intervention Type DEVICE

Drug-eluting balloon

After passing the stenosis it is dilated with a conventional balloon. The patient is randomized to a second dilatation with a drug-eluting balloon

Intervention Type DEVICE

Other Intervention Names

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PTA (percutaneous transluminal angioplasty) Balloon angioplasty DEB

Eligibility Criteria

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Inclusion Criteria

* Any venous bypass with stenosis warranting intervention

Exclusion Criteria

* Previous PTA with drug-eluting balloon, thrombolysis, coagulopathy
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Helsinki University Central Hospital

OTHER

Sponsor Role lead

Responsible Party

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Maarit Venermo

Professor of Vascular Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Maarit Venermo, M.D., Ph.D.

Role: STUDY_DIRECTOR

Helsinki University Hospital, Dept. of Vascular Surgery

Locations

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Helsinki University Hospital

Helsinki, , Finland

Site Status

Countries

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Finland

References

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Bjorkman P, Kokkonen T, Alback A, Venermo M. Drug-Coated versus Plain Balloon Angioplasty in Bypass Vein Grafts (the DRECOREST I-Study). Ann Vasc Surg. 2019 Feb;55:36-44. doi: 10.1016/j.avsg.2018.04.042. Epub 2018 Aug 6.

Reference Type DERIVED
PMID: 30092443 (View on PubMed)

Other Identifiers

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DRECOREST1 - Jan 23rd 2013

Identifier Type: -

Identifier Source: org_study_id

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