Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia

NCT ID: NCT02563535

Last Updated: 2020-01-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

105 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-09-30

Study Completion Date

2020-01-31

Brief Summary

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The aim of this study is to evaluate the potential advantage in terms of late lumen loss reduction of Litos drug-eluting balloon vs standard percutaneous transluminal angioplasty in the treatment of below-the-knee disease in patients with critical limb ischemia.

Detailed Description

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Conditions

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Peripheral Artery Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Drug-eluting balloon

angioplasty with Litos drug-eluting balloon

Group Type EXPERIMENTAL

DEB

Intervention Type DEVICE

angioplasty with Litos drug eluting balloon

conventional PTA

angioplasty with conventional balloon

Group Type ACTIVE_COMPARATOR

PTA

Intervention Type DEVICE

angioplasty with conventional balloon

Interventions

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DEB

angioplasty with Litos drug eluting balloon

Intervention Type DEVICE

PTA

angioplasty with conventional balloon

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* age\>18 years
* critical limb ischemia (Rutherford class 4-6)
* angiographic stenosis\>50% or occlusion of at least one tibial vessel of at least 40mm for which an interventional treatment is scheduled

Exclusion Criteria

* need for major amputation known before intervention
* allergy to Paclitaxel
* contraindication for combined antiplatelet treatment
* life expectancy \<1 year
* hypersensitivity or contraindication to one of the study drugs
* lack of consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ospedale San Donato

OTHER

Sponsor Role lead

Responsible Party

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Leonardo Bolognese, MD

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Cardiovascular Department, Ospedale S.Donato

Arezzo, AR, Italy

Site Status

Countries

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Italy

Other Identifiers

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Arezzo015

Identifier Type: -

Identifier Source: org_study_id

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