Compare Two Anti-Scorpion Venom Serum In Children

NCT ID: NCT01415830

Last Updated: 2013-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-08-31

Study Completion Date

2012-05-31

Brief Summary

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The morbidity associated with scorpion sting intoxication presents an endemic pattern in the country, where there are highly venomous species of scorpions so the scorpion sting intoxication (IPPA) is considered a medical emergency.

On the other hand, there is scarce scientific literature from different controlled studies evaluating anti-scorpion serum, considering clinical severity scales, lab results and their safety. The aim of this study is to compare the efficacy and safety of scorpion sting treatment, using two sera, one produced by Birmex versus Alacramyn ® (Bioclon).

Detailed Description

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We consider relevant conduct this study because the poisoning scorpion bite represents a public health problem.

This is a randomized clinical trial, which included 120 subjects of both sexes aged 0 and 15 years old and residents of the state of Guanajuato, divided into 2 groups: 60 patients received antiscorpion serum of Birmex and 60 patients receive other commercial serum (Alacramyn).

Conditions

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Scorpion Sting

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Anti-scorpion venom serum Birmex

Patients 0 to 15 years with scorpion sting, will receive serum antiscorpion elaborated by Birmex

Group Type EXPERIMENTAL

Anti-scorpion venom serum Alacramyn

Intervention Type BIOLOGICAL

The dose may be required fot the patient according to clinical manifestations and evolution

Anti-scorpion venom serum Alacramyn

Patients 0 to 15 years with scorpion sting, will receive other commercial serum antiscorpion (Alacramyn)

Group Type ACTIVE_COMPARATOR

Anti-scorpion venom serum Birmex

Intervention Type BIOLOGICAL

the dose may be required for the patient according to clinical manifestations and evolution

Interventions

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Anti-scorpion venom serum Birmex

the dose may be required for the patient according to clinical manifestations and evolution

Intervention Type BIOLOGICAL

Anti-scorpion venom serum Alacramyn

The dose may be required fot the patient according to clinical manifestations and evolution

Intervention Type BIOLOGICAL

Other Intervention Names

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anti-scorpion venom serum antiscorpion venom serum

Eligibility Criteria

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Inclusion Criteria

1. Scorpion sting
2. Either sex
3. Age 1 to 15 years
4. Signing an informed consent (signed by parent or guardian)
5. Being residents of the state of Guanajuato

Exclusion Criteria

1. Previous treatment with gamma globulin or immunoglobulin
2. Blood transfusion at any stage of life
3. Patients treated with drugs that interact with anti-scorpion serum
4. History or history of sensitivity or intolerance to anti-scorpion serum or horse products
5. Pregnancy
6. Any immunodeficiency
7. Patients who have participated in a research protocol in the previous month.
Minimum Eligible Age

1 Year

Maximum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Laboratorios de Biologicos y Reactivos de México, S.A. de C.V.

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ma. Eugenia Jimenez-Corona, PhD

Role: PRINCIPAL_INVESTIGATOR

Laboratorios de Biologicos y Reactivos de México SA de CV

Locations

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Hospital General Regional de León

León, Guanajuato, Mexico

Site Status

Countries

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Mexico

Other Identifiers

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BIRMEX-ECA-03-2011

Identifier Type: -

Identifier Source: org_study_id

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