Etude 3000 ARTHROSES Symptomatic Knee and Hip Osteoarthritis Prevalence Survey

NCT ID: NCT01400529

Last Updated: 2011-07-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

3000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-03-31

Study Completion Date

2009-11-30

Brief Summary

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Nationwide descriptive epidemiology survey aiming to determine lower limb OA prevalence, based on a validated method previously used to assess inflammatory rheumatism (rheumatoid arthritis and spondylarthropathy) prevalence in France.

Detailed Description

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Osteoarthritis (OA) is a degenerative disease progressively affecting joint cartilage and subchondral bone, leading to pain, limited range of motion and functional impairment. Knee and hip are the more frequently affected joints. There is no treatment able to cure OA or at least to slow down cartilage damage. Thus, when symptomatic treatments become ineffective, joint prosthetic replacement is the unique solution.

There is a substantial lack of information about osteoarthritis (OA) epidemiology in France, as well as in other European countries, which becomes more and more critical with population aging. The need for additional knowledge was outlined in the law about public health priorities in France, published on August 9th, 2004. In this document, a specific call is made for additional investigation on functional limitations, disability and quality of life modification of people affected by OA.

Up to now, available information is mainly limited to short- or medium-term studies, conducted in clinic-based samples. Thus, based on demography and public health conclusions, implementing population-based epidemiologic studies is required in order to improve scientific knowledge with regards to :

* prevalence of symptomatic OA,
* its natural history over years and potential prognostic factors influencing the disease,
* its impact in terms of quality of life changes, disability, lack of autonomy and health resource use.

Our expert group, which has a substantial experience in osteoarthritis, epidemiology and health service research, has developed a 2-part research program aiming to help answering to OA-related public health questions:

* Part 1: a nationwide descriptive epidemiology survey aiming to determine lower limb OA prevalence, based on a validated method previously used to assess inflammatory rheumatism (rheumatoid arthritis and spondylarthropathy) prevalence in France.
* Part 2: the constitution of a population-based cohort of OA patients, aiming to collect clinical, biologic and radiological data about OA natural history, predictors of structural progression, consequences on quality of life, function and health resource use.

The present study is the part 1 of the program

Conditions

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Osteoarthritis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* age 40-75
* adults in households representative of the French population for age, sex, area of living and number of household members.
Minimum Eligible Age

40 Months

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Central Hospital, Nancy, France

OTHER

Sponsor Role lead

Responsible Party

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Central Hospital, Nancy, France

Principal Investigators

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Francis Guillemin, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Societe Francaise de Rhumatologie

Locations

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Service de Rhumatologie. CHU d'Amiens

Amiens, , France

Site Status

Service de Rhumatologie. CHU de la Cavale Blanche

Brest, , France

Site Status

Centre d'Epidémiologie Clinique. Service de rhumatologie. CHU Nancy

Nancy, , France

Site Status

Service de Rhumatologie. CHU L'Archet 1

Nice, , France

Site Status

Service de Rhumatologie. Hôpital de la Pitié-Salpêtrière

Paris, , France

Site Status

Service de Rhumatologie. Hôpital Rangueil

Toulouse, , France

Site Status

Countries

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France

References

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Guillemin F, Rat AC, Mazieres B, Pouchot J, Fautrel B, Euller-Ziegler L, Fardellone P, Morvan J, Roux CH, Verrouil E, Saraux A, Coste J; 3000 Osteoarthritis group. Prevalence of symptomatic hip and knee osteoarthritis: a two-phase population-based survey. Osteoarthritis Cartilage. 2011 Nov;19(11):1314-22. doi: 10.1016/j.joca.2011.08.004. Epub 2011 Aug 16.

Reference Type DERIVED
PMID: 21875676 (View on PubMed)

Other Identifiers

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906297

Identifier Type: -

Identifier Source: org_study_id

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