A Population-based Cohort of Osteoarthritis: the Xiangya Osteoarthritis Study
NCT ID: NCT04033757
Last Updated: 2022-04-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
4080 participants
OBSERVATIONAL
2015-11-17
2031-12-31
Brief Summary
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Detailed Description
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1. To understand the natural history of osteoarthritis (OA) at different joints (knee, hip, hand, foot and lumbar).
2. To identify different phenotypes of OA (e.g., generalized OA, rapidly progressive knee and hand OA, tibiofemoral OA and patellofemoral OA), their association with pain (e.g., peripheral pain, central pain, nociceptive pain and neuropathic pain) and consequences.
3. To examine risk factors of OA (lifestyle habits, nutritional, metabolic, anatomical and genetic factors, etc.) at each joint as well as multiple joints.
4. To determine the association between x-ray structure change, ultrasound synovial changes and pain and other symptoms of OA at knee and hand joints within the large-sample community-based population.
5. To predict the progression of knee and hand OA within new-onset early-stage knee and hand OA patients, and to identify the rapidly progressive knee and hand OA phenotypes and their related risk factors.
6. To investigate the association between gut microbiota and OA.
7. To investigate the association between oral microbiota and OA.
Design: This is a prospective community-based cohort study.
Participants: Subjects included in this study were a randomly selected sample of residents, aged 50 years or older from rural mountainous communities of Longshan County, Hunan Province, China. 4000 people were planned to be recruited, divided into three sub-cohorts. 1,469 participants were enrolled in sub-cohort 1 in 2015, and two follow-ups have been completed in 2016 and 2017. 1,267 participants were enrolled in sub-cohort 2 in 2018. 1,340 participants were enrolled in sub-cohort 3 in 2019. Each sub-cohort will be followed every three years regularly.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Sub-cohort 1
1,469 participants were enrolled in 2015. Three follow-ups have been completed in 2016, 2017, and 2020. They will be asked to participate in follow-up in 2023 and 2026.
No interventions assigned to this group
Sub-cohort 2
1,267 participants were enrolled in 2018. They will be asked to participate in follow-up in 2021, 2024, 2027, and 2030.
No interventions assigned to this group
Sub-cohort 3
1,340 participants were enrolled in 2019. They will be asked to participate in follow-up in 2022, 2025, 2028, and 2031.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
2. Residents of the randomly selected communities
Exclusion Criteria
2. Terminal or mental illness
3. Pregnant women
50 Years
ALL
Yes
Sponsors
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University of Nottingham
OTHER
Harvard University
OTHER
Xiangya Hospital of Central South University
OTHER
Responsible Party
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Principal Investigators
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Guanghua Lei, Doctor
Role: STUDY_CHAIR
Xiangya Hospital of Central South University
Locations
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Xiangya Hospital of Central South University
Changsha, Hunan, China
Countries
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References
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Zhu Y, Li J, Zhang Y, Zhang W, Doherty M, Yang Z, Cui Y, Zeng C, Lei G, Yang T, Wei J. Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study. RMD Open. 2023 Dec 1;9(4):e003683. doi: 10.1136/rmdopen-2023-003683.
Other Identifiers
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201510506
Identifier Type: -
Identifier Source: org_study_id
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