Osteoarthritis and Body Composition: Evaluation of Systematic Mediators
NCT ID: NCT00771082
Last Updated: 2012-06-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
1033 participants
OBSERVATIONAL
2003-01-31
2012-12-31
Brief Summary
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Detailed Description
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The specific aims of this study are to:
1. Examine the association between prevalent radiographic osteoarthritis (OA), concurrently obtained inflammatory and metabolic mediator levels and change in bone density and bone markers over time subsequent to radiographic classification.
2. Determine levels of inflammatory, metabolic and bone markers, and body composition when radiographic OA was absent, and examine their relationship to the development of radiographic knee OA.
Adjustments will be made for age, gender, body mass index and level of physical activity.
Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Diagnosis of malignancy
* Reported use of prednisone and other immunosuppressive medications or insulin
20 Years
ALL
Yes
Sponsors
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National Institute on Aging (NIA)
NIH
Responsible Party
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National Institute on Aging
Principal Investigators
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Shari Ling, MD
Role: PRINCIPAL_INVESTIGATOR
National Institute on Aging (NIA)
Locations
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National Institute on Aging
Baltimore, Maryland, United States
Countries
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References
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Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum. 1998 Aug;41(8):1343-55. doi: 10.1002/1529-0131(199808)41:83.0.CO;2-9. No abstract available.
Hochberg MC, Lethbridge-Cejku M, Scott WW Jr, Reichle R, Plato CC, Tobin JD. The association of body weight, body fatness and body fat distribution with osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. J Rheumatol. 1995 Mar;22(3):488-93.
Lethbridge-Cejku M, Tobin JD, Scott WW Jr, Reichle R, Roy TA, Plato CC, Hochberg MC. Axial and hip bone mineral density and radiographic changes of osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. J Rheumatol. 1996 Nov;23(11):1943-7.
Sharif M, Shepstone L, Elson CJ, Dieppe PA, Kirwan JR. Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee. Ann Rheum Dis. 2000 Jan;59(1):71-4. doi: 10.1136/ard.59.1.71.
Other Identifiers
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AG0109
Identifier Type: -
Identifier Source: org_study_id
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