Effect of Exercise on the Disease Activity of Rheumatoid Arthritis

NCT ID: NCT00792675

Last Updated: 2023-08-30

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 55 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2003-01-01
• Study Completion Date: 2006-11-01

Brief Summary

This study will evaluate the effect of exercise on the number of swollen and tender joints associated with rheumatoid arthritis after a 12 week exercise program of treadmill walking and weightlifting.

Detailed Description

The goal of this study was to evaluate the effect of exercise on the number of swollen and tender joints associated with rheumatoid arthritis. It was hypothesized that persons would have less inflammation associated with rheumatoid arthritis after a 12 week exercise program of treadmill walking and weighlifting. Immune parameters were measured to determine potential mechanisms responsible for changes in inflammation with exercise.

Conditions

Rheumatoid Arthritis

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Exercise

Exercise consists of 30 minutes of treadmill exercise at approximately 85% of heart rate max and 2 sets of 6 resistance weight lifting exercises resulting in volitional fatigue at 12 to 15 repetitions.

Group Type: EXPERIMENTAL

Aerobic and resistance exercise training

Intervention Type: OTHER

Exercise was performed 3 times per week. It consisted of 30 minutes of treadmill exercise at approximately 85% of heartrate max and 2 sets of 6 resistance weight lifting exercises resulting in volitional fatigue at 12 to 15 repetitions.

Interventions

Aerobic and resistance exercise training

Exercise was performed 3 times per week. It consisted of 30 minutes of treadmill exercise at approximately 85% of heartrate max and 2 sets of 6 resistance weight lifting exercises resulting in volitional fatigue at 12 to 15 repetitions.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• a diagnosis of RA according to the ACR 1989 Criteria at least 6 months prior to enrollment in the study, but not longer than 12 years
• age 19 to 65 years old
• stable regimen of medication for 2 months with less than 10 mg/day of oral corticosteroids
• currently exercise < 2x/week for less than 30 minutes at less than 60% of his/her age predicted maximum heart rate
• Subjects must pass the Physical Activity Readiness Scale Questionnaire (PAR-Q)

Exclusion Criteria

• other serious health problems
• intra-articular injection within 6 weeks
• total joint replacement of the large joints
• use of beta-blockers
• inability to complete the submaximal exercise test

• Minimum Eligible Age: 19 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Arthritis Foundation

OTHER

Sponsor Role: collaborator

Nebraska Chapter Arthritis Foundation

UNKNOWN

Sponsor Role: collaborator

University of Nebraska

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Laura D Bilek, PhD, PT

Role: PRINCIPAL_INVESTIGATOR

University of Nebraska

Locations

Physical Activity Lab, University of Nebraska Omaha

Omaha, Nebraska, United States

Countries

United States

Other Identifiers

0267-02-FB

Identifier Type: -

Identifier Source: org_study_id