Breaking up Sedentary Time in Rheumatoid Arthritis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-12-01

Study Completion Date

2024-12-01

Brief Summary

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This study will verify the effects of breaking up sitting time with short bouts of light intensity walking on vascular function in women with rheumatoid arthritis.

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Detailed Description

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Women diagnosed with rheumatoid arthritis will participate in this randomized crossover trial. In one of the experimental sessions, the participants will remain 4-h on uninterrupted sitting, and in another day they will perform 3-min light intensity walk every 30 min to break up the sitting position. Vascular function will be assessed before and after each intervention using the following devices/techniques: a) transcranial Doppler ultrasound to assess the middle cerebral artery blood flow velocity at baseline and in response to CO2 breathing (5% CO2 mixture for 3 min), and to repeated sit-to-stand transitions; b) a multi-frequency linear transducer (7-12 MHz) attached to a high-resolution ultrasound machine to assess femoral artery dilation after reactive hyperemia (i.e., flow-mediated dilation); c) a laser Doppler probe attached to the skin surface of the right shin in order to quantify the Laser Doppler flux at baseline and during reactive hyperemia. Additionally, healthy age- and body mass-matched women will be recruited and will only perform the pre-intervention tests.

Conditions

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Rheumatoid Arthritis Sedentary Behavior Endothelial Dysfunction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Participants with rheumatoid arthritis will attend the laboratory at Liverpool John Moores University on 2 occasions. During these visits, they will be submitted to the intervention or the control and will also undertake a series vascular tests prior- and post-intervention/control.

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Outcome Assessors

The researcher who will perform the vascular analysis will be blinded to the allocation order.

Study Groups

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Walking breaks (WALK)

During this session, participants will be requested to remain seated during 4 hours, but the sitting will be interrupted every 30 min with a 3-min light-intensity walking.

Group Type EXPERIMENTAL

Physical activity

Intervention Type BEHAVIORAL

Multiple bouts of 3-min brisk walking, every 30 min, for 4 hours.

Prolonged sitting (SIT)

During this session, participants be requested to remain seated during 4 uninterrupted hours (excepted for visiting the toilet) in a comfortable chair

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Physical activity

Multiple bouts of 3-min brisk walking, every 30 min, for 4 hours.

Intervention Type BEHAVIORAL

Other Intervention Names

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Walking

Eligibility Criteria

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Inclusion Criteria

* Adult women diagnosed with RA
* From the Rheumatology Clinic at the Liverpool University Hospitals NHS Foundation Trust
* Aged 18-60 yr
* Non-smoker for at least 6months
* Able to provide written informed consent.

Exclusion Criteria

* Cannot readily read and understand English.
* Currently smoking or within last 6 months.
* Alcohol consumption \>14units per week.
* Symptoms of or established cardiovascular disease (except hypertension)
* Previous stroke or myocardial infarction.
* History of diabetes or respiratory disease or chronic kidney disease.
* Musculoskeletal impairment/disability precluding physical activity
* Unstable medication (change in medication within the 3 months)
* Aged \<18 or \> 60 yr
* Currently pregnant

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No