The Effects Of Low Intensity Training With Blood Flow Restriction In Rheumatoid Arthritis Patients

NCT ID: NCT05869370

Last Updated: 2023-05-22

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 28 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-05-20
• Study Completion Date: 2025-12-31

Brief Summary

Rheumatoid arthritis (RA) patients showed systemic manifestations that may lead to a reduction in muscle strength, muscle mass and, consequently, to a reduction in physical function. On the other hand, high intensity resistance training (HIRT) are able to improve muscle strength and muscle mass in RA without affecting the disease course. However, due to the articular manifestations caused by this disease, these patients may present intolerance to HIRT. Thus, the low intensity resistance training with blood flow restriction (TBFR) may be a new training strategy for these populations. In this sense, the investigators speculate that TBFR could be beneficial in RA patients, as well as, HIRT.

Conditions

Rheumatoid Arthritis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

High intensity resistance training

Group Type: EXPERIMENTAL

High intensity resistance training

Intervention Type: OTHER

Twelve weeks of resistance training twice a week.

Low intensity resistance training combined with blood flow restriction

Group Type: EXPERIMENTAL

Low intensity resistance training combined with blood flow restriction

Intervention Type: OTHER

Twelve weeks of resistance training with blood flow restriction twice a week.

Interventions

High intensity resistance training

Twelve weeks of resistance training twice a week.

Intervention Type: OTHER

Low intensity resistance training combined with blood flow restriction

Twelve weeks of resistance training with blood flow restriction twice a week.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Female;
• Rheumatoid arthritis patients;
• All individuals will undergo an ergospirometry to ensure cardiorespiratory conditions.

Exclusion Criteria

• Fibromyalgia;
• Cardiovascular disease;

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Hospital de Clínicas de Porto Alegre

UNKNOWN

Sponsor Role: collaborator

Federal University of Rio Grande do Sul

OTHER

Sponsor Role: lead

Responsible Party

Ricardo Machado Xavier

PhD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Universidade Federal do Rio Grande do Sul - Faculdade de Medicina - Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Site Status: RECRUITING

Countries

Brazil

Facility Contacts

Leonardo P. dos Santos, Master's degree

Role: primary

leonardosantos@hcpa.edu.br

+55 (51)9 92840819

References

Dos Santos LP, Santo RCDE, Ramis TR, Portes JKS, Chakr RMDS, Xavier RM. The effects of resistance training with blood flow restriction on muscle strength, muscle hypertrophy and functionality in patients with osteoarthritis and rheumatoid arthritis: A systematic review with meta-analysis. PLoS One. 2021 Nov 10;16(11):e0259574. doi: 10.1371/journal.pone.0259574. eCollection 2021.

Reference Type: BACKGROUND

PMID: 34758045 (View on PubMed)

Other Identifiers

2018-0071

Identifier Type: -

Identifier Source: org_study_id