Effect of Quadriceps Muscle on Physical Outcome Measures in Women With Rheumatoid Arthritis

NCT ID: NCT06197074

Last Updated: 2024-01-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

102 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-25

Study Completion Date

2025-12-25

Brief Summary

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Studies have reported that individuals with Rheumatoid Arthritis have a smaller muscle cross-sectional area, pennation angle and muscle thickness than healthy controls. Sarcopenia may decrease physical performance and quality of life in individuals with RA. Therefore, morphologic changes in the quadriceps femoris muscle due to sarcopenia may help us to gain insight into physical function and quality of life. This study aims to evaluate the predictive capacity of morphologic characteristics of the quadriceps femoris muscle for disease activity, physical performance, and quality of life in women with Rheumatoid Arthritis.

Detailed Description

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Studies have reported that individuals with Rheumatoid Arthritis have a smaller muscle cross-sectional area, pennation angle and muscle thickness than healthy controls. Sarcopenia may decrease physical performance and quality of life in individuals with RA. Therefore, morphologic changes in the quadriceps femoris muscle due to sarcopenia may help us to gain insight into physical function and quality of life. This study aims to evaluate the predictive capacity of morphologic characteristics of the quadriceps femoris muscle for disease activity, physical performance, and quality of life in women with Rheumatoid Arthritis.

Within the scope of the study, the morphological characteristics of the quadriceps muscle of the participants will be evaluated by a Physical Medicine and Rehabilitation specialist physician via ultrasound. After appropriate visualization, the image will be captured and saved in JPEG format, and will be exported to the ImageJ program for further analysis and evaluations will be performed by an anatomist. Assessments of quality of life and physical performance will be made by a physiotherapist involved in the study.

Conditions

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Rheumatoid Arthritis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Interventions

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Ultrasound assessment

The morphological characteristics of the quadriceps muscle of the participants will be assessed using ultrasound.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18-60 years old
* Female participants with a confirmed diagnosis of RA for at least 3 years according to the 2010 American College of Rheumatology (ACR) criteria
* Presence of sarcopenia

Exclusion Criteria

* Presence of fractures, burns or lesions in the area to be measured
* Presence of any neuromuscular, cardiovascular or metabolic disease,
* Individuals with knee endoprosthesis,
* Inability to walk
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Afyonkarahisar Health Sciences University

OTHER

Sponsor Role lead

Responsible Party

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Erdal Horata

PhD; Lecturer; Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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ERDAL HORATA, PhD

Role: PRINCIPAL_INVESTIGATOR

Afyonkarahisar Health Sciences University

Locations

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Afyonkarahisar Health Sciences University

Afyonkarahisar, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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ERDAL HORATA, PhD

Role: CONTACT

+905056092631

Facility Contacts

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ERDAL HORATA, PhD

Role: primary

+905056092631

Other Identifiers

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2023/8

Identifier Type: -

Identifier Source: org_study_id

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