Effectiveness of Water Exercises on Isokinetic Muscle Strength

NCT ID: NCT01447264

Last Updated: 2011-10-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-02-28

Study Completion Date

2011-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The interest in studying the impact of aquatic exercise on muscle strength of patients with rheumatoid arthritis came after publication of several studies that pointed to the potential benefit of exercise on the natural history of the disease, including reduction of pain, better immune response as well as aerobic fitness and functional capacity and increase muscle strength, endurance and quality of life.

In general, the aquatic exercises are indicated for patients with chronic joint diseases, since the aquatic environment seems to be more secure for this population due to the reduction of joint loading, as well as gain range of motion.

However, there are some difficulties to show the real and consistent beneficial effect of physical activity in these patients, such as the small number of randomized controlled clinical trials, short intervention period (4-8 weeks), lack of details of the exercise protocols used, methodological problems (heterogeneous measures to evaluate the outcome, change of medication). Moreover, no study evaluated the disease activity, according to the tool most used clinically worldwide, the DAS28.

It is known that aquatic exercises without impact in healthy subjects are sufficient to gain muscle strength. Nonetheless, in people with joint limitation the benefits from these same exercises to gain muscle strength is not known.

To date, no studies addressing the effect of aquatic exercise on muscle strength and disease activity in patients with rheumatoid arthritis. In addition, there is the need to obtain a standardized protocol for prescribing of aquatic exercises. The choice of lower-limb strength was based on its relevance to the acceleration and deceleration during the march, as well as to perform activities of daily living, leisure and professional in these individuals.

Thus, this study aims at:

1. Exercises performed in the aquatic environment and without the concomitant use of overhead equipment are sufficient to promote gain muscle strength in the lower limb?
2. What is the isolated effect of water resistance on muscle strength? Could it work as an impact that is used in exercises done on the land?

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The investigators objectives are:

* To compare the peak torque of flexor and extensor of the knee between land and water exercises in women with rheumatoid arthritis. This is a randomized controlled clinical trial with 16 weeks of length;
* To verify the changes of disease activity, functional capacity and body composition measurements before and after the intervention

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Rheumatoid Arthritis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Land exercises

The patients of this group will perform the same exercises from water exercises

Group Type PLACEBO_COMPARATOR

Land exercises

Intervention Type PROCEDURE

3 times a week. 50 minutes in every session. Performed by educational professor

Water exercises

The patients of this group will perform the same exercises from land exercises

Group Type ACTIVE_COMPARATOR

Water exercises

Intervention Type PROCEDURE

3 times a week. 50 minutes in every session. Performed by educational professor

Control group

No intervention will be recommended

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Land exercises

3 times a week. 50 minutes in every session. Performed by educational professor

Intervention Type PROCEDURE

Water exercises

3 times a week. 50 minutes in every session. Performed by educational professor

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Females;
* Pre- or postmenopausal;
* Disease Activity: from mild to moderate, according to the DAS28;
* Functional class I and II Steinbrocker;
* No rehabilitation program in the last three months;
* Stable medication in the three months before randomization;
* Cardiorespiratory fitness after exercise testing and cardiologic exam;
* Agree and sign the Instrument of Consent;

Exclusion Criteria

* Circulatory problems, ulcers in the legs, or other untreated skin lesions that would preclude the exercise in the pool;
* Physical activity regularly in the three months prior to intervention;
* Use of orthoses or any other devices;
* Hip or knee prosthesis;
* Regular use of proteic supplements or anabolic drugs;
* Orthopedic surgery scheduled for the next six months;
* Intra-articular infiltration in the three months prior to randomization or scheduled for the next six months;
* Illiteracy and cognitive impairment;
* Hearing loss and visual;
* Phobia of water;
* Hypersensitivity to the chlorine;
* Epilepsy and urinary or fecal incontinence;
* Any uncontrolled chronic illness.
Minimum Eligible Age

40 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Department of Medicine

AMBIG

Sponsor Role collaborator

Federal University of São Paulo

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Marcelo M Pinheiro

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Marcelo M Pinheiro, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Federal University of São Paulo

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Federal University of Sao Paulo

São Paulo, São Paulo, Brazil

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Brazil

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

FUSaoPaulo-01

Identifier Type: -

Identifier Source: org_study_id