Physical Exercise as a Targeted Therapy in Patients With Chronic Rheumatic Muscle Inflammation
NCT ID: NCT01184625
Last Updated: 2011-06-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2008-01-31
2012-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Exercise
Physical Exercise
12 weeks of physical exercise.
No intervention
12 weeks of stable physical exercise level.
No interventions assigned to this group
Interventions
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Physical Exercise
12 weeks of physical exercise.
Eligibility Criteria
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Inclusion Criteria
* Age 18-80 years
* Duration since diagnosis \> 6 months
* Exercising \< once a week,
* Stable disease activity and medication for at least one month.
Ten healthy controls matched for age, gender and physical exercise level will be included.
\-
Exclusion Criteria
* Heart or lung conditions that contraindicate vigorous exercise
* Severe osteoporosis
* Not being able to perform the exercise program.
18 Years
80 Years
ALL
Yes
Sponsors
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Uppsala University Hospital
OTHER
Sahlgrenska University Hospital
OTHER
Karolinska Institutet
OTHER
Responsible Party
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Karolinska Institutet
Principal Investigators
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Ingrid E Lundberg, MD, PhD, Prof
Role: PRINCIPAL_INVESTIGATOR
Rheumatology Unit, Department of Medicine, in Solna, Karolinska Institutet
Locations
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Rheumatology unit, Karolinska University Hospital
Stockholm, , Sweden
Countries
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Central Contacts
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Facility Contacts
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References
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Boehler JF, Hogarth MW, Barberio MD, Novak JS, Ghimbovschi S, Brown KJ, Alemo Munters L, Loell I, Chen YW, Gordish-Dressman H, Alexanderson H, Lundberg IE, Nagaraju K. Effect of endurance exercise on microRNAs in myositis skeletal muscle-A randomized controlled study. PLoS One. 2017 Aug 22;12(8):e0183292. doi: 10.1371/journal.pone.0183292. eCollection 2017.
Alemo Munters L, Dastmalchi M, Katz A, Esbjornsson M, Loell I, Hanna B, Liden M, Westerblad H, Lundberg IE, Alexanderson H. Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis. Arthritis Res Ther. 2013 Aug 13;15(4):R83. doi: 10.1186/ar4263.
Alemo Munters L, Dastmalchi M, Andgren V, Emilson C, Bergegard J, Regardt M, Johansson A, Orefelt Tholander I, Hanna B, Liden M, Esbjornsson M, Alexanderson H. Improvement in health and possible reduction in disease activity using endurance exercise in patients with established polymyositis and dermatomyositis: a multicenter randomized controlled trial with a 1-year open extension followup. Arthritis Care Res (Hoboken). 2013 Dec;65(12):1959-68. doi: 10.1002/acr.22068.
Other Identifiers
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Exercise
Identifier Type: -
Identifier Source: org_study_id
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