A Population-based Cohort of Osteoarthritis: the Tsinghua University Tiantongyuan Community Osteoarthritis Study

NCT ID: NCT07006701

Last Updated: 2025-06-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

4000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-03

Study Completion Date

2034-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to examine the natural history and risk factors of osteoarthritis (OA) and to explore the relationship between metabolic factors and OA progression.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

1. To investigate the natural history of osteoarthritis (OA) in a large-sample cohort.
2. To identify OA phenotypes and their relationship with clinical symptoms and functional impairment.
3. To analyze metabolic factors (e.g., obesity, diabetes, and hypertension) as risk factors for OA onset and progression.
4. To evaluate the association between radiographic changes and OA symptoms.
5. To develop predictive models for OA progression and identify high-risk individuals for early intervention.

Design: This is a prospective cohort study. Participants: The study will recruit approximately 4,000 individuals aged 50 years and above. Participants will undergo baseline assessments, including demographic data collection, medical history, dietary evaluation, physical examination, blood sample collection, and radiographic imaging. Annual follow-ups will be conducted over 10 years to monitor OA progression and related risk factors.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Osteoarthritis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Aged 50 years and above
* Long-term resident of the study area
* Willing to participate and provide informed consent

Exclusion Criteria

* Hearing, speech, or mental impairments preventing effective communication
* Unable to complete scheduled follow-up visits
* Pregnant or planning pregnancy during the study period
* Any other condition deemed unsuitable for participation by the researchers
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Beijing Tsinghua Chang Gung Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Beijing Tsinghua Chang Gung Hospital

Beijing, Beijing Municipality, China

Site Status

Countries

Review the countries where the study has at least one active or historical site.

China

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

25025-4-01

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

The Osteoarthritis Prevention Study
NCT05946044 RECRUITING NA
Health Promotion of People With Disabilities
NCT00164489 COMPLETED PHASE2/PHASE3
DIGItal Cohort Osteoarthritis Design
NCT01831570 ACTIVE_NOT_RECRUITING NA
Cognition, Pain and Wellbeing
NCT04620525 TERMINATED