Relationship Between Rheumatoid Arthritis Severity and Cognition in the Elderly: The Role of Nociplastic Pain

NCT ID: NCT05934721

Last Updated: 2023-07-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-07-15

Study Completion Date

2023-12-31

Brief Summary

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this study aims to determine if nociplastic pain mediates the relationship between rheumatoid arthritis (RA) severity and cognitive impairment in geriatric patients 100 patients aged 65-90 years with long-standing RA and assess their disease severity, cognition, and pain sensitization will be recruited. Expectations that patients with more severe RA will have worse cognitive function, and that this relationship will be mediated by higher levels of nociplastic pain.

Detailed Description

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Conditions

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Rheumatoid Arthritis Rheumatic Diseases Rheumatoid Polyarthritis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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RA patients aged 70-90 years

Patients meeting inclusion/exclusion criteria will be recruited from rheumatology clinics and community sources.

Questionnaire and physical assessments

Intervention Type OTHER

Participants will complete self-report questionnaires assessing pain (CSI) and RA severity (patient global VAS), as well as undergoing physical assessments of RA severity (physician global VAS, swollen/tender joint counts) and cognition (MoCA).

Interventions

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Questionnaire and physical assessments

Participants will complete self-report questionnaires assessing pain (CSI) and RA severity (patient global VAS), as well as undergoing physical assessments of RA severity (physician global VAS, swollen/tender joint counts) and cognition (MoCA).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age 65-90 years
* diagnosed with RA for 10-30 years
* meet ACR/EULAR 2010 criteria

Exclusion Criteria

* Other inflammatory arthritides
* dementia
* severe depression
* recent corticosteroid or immunosuppressant use
Minimum Eligible Age

65 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ahram Canadian University

OTHER

Sponsor Role lead

Responsible Party

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Mohamed Magdy ElMeligie

Lecturer of Physical Therapy and Director of Electromyography Lab

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Amal Fawzy, Ph.d

Role: STUDY_DIRECTOR

Faculty of Physical Therapy, Ahram Canadian University

Locations

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Outpatient clinic of faculty of physical therapy, Ahram Canadian University

Al Ḩayy Ath Thāmin, Giza Governorate, Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Mohamed M ElMeligie, Ph.d

Role: CONTACT

+201064442032

Facility Contacts

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Mohamed M ElMeligie, Ph.d

Role: primary

01064442032

Other Identifiers

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012/282023062023

Identifier Type: -

Identifier Source: org_study_id

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