Effect of Smoking on Pain and Atherosclerosis in Patients With Rheumatoid Arthritis

NCT ID: NCT03449589

Last Updated: 2022-05-04

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Total Enrollment: 1000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2011-11-30
• Study Completion Date: 2025-11-30

Brief Summary

Primary aim: examine a possible connection between cigarette smoking, disease activity and perceived pain in patients with rheumatoid arthritis.

Secondary aim: Evaluate cardiovascular risk in patients with rheumatoid arthritis.

Detailed Description

The study will recruit patients with rheumatoid arthritis (age 20-60 years) at rheumatology clinics in Västra Götaland. All patients meeting the inclusion criteria will be informed of the study in a letter and later contacted by the study coordinator and if interested booked for a study visit at the rheumatology clinic. At the study visit the patients will meet with rheumatologist for clinical examination of their joints and tenderpoints. An algometer is used for objective quantification of the patients pain sensitivity. Questionnaire regarding medical treatment, other diseases, smoking habits, subjective pain, fatigue, anxiety and depression, ability to work and ability to perform everyday activities are filled out by the patient.

Height, weight, blood pressure, blood, urine and fat biopsy will be collected for analyse.

Conditions

Rheumatoid Arthritis; Atherosclerosis; Pain

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Smokers

RA patients currently smoking

No interventions assigned to this group

Former smokers

RA patients who previously smoked

No interventions assigned to this group

Non smokers

Non smoking RA patients

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Patients aged 20-60 years diagnosed with rheumatoid arthritis

Exclusion Criteria

• Other serious physical or mental illness, lack of knowledge in Swedish language making answering the questionnaires impossible

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Vastra Gotaland Region

OTHER_GOV

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Dept of Rheumatology and Inflammation research

Gothenburg, , Sweden

Countries

Sweden

References

Erlandsson MC, Malmhall-Bah E, Chandrasekaran V, Andersson KME, Nilsson LM, Toyra Silfversward S, Pullerits R, Bokarewa MI. Insulin Sensitivity Controls Activity of Pathogenic CD4+ T Cells in Rheumatoid Arthritis. Cells. 2024 Dec 22;13(24):2124. doi: 10.3390/cells13242124.

Reference Type: DERIVED

PMID: 39768214 (View on PubMed)

Lyngfelt LI, Erlandsson MC, Nadali M, Hedjazifar S, Pullerits R, Andersson KM, Brembeck P, Silfversward ST, Smith U, Bokarewa MI. Impact of the Uncoupling Protein 1 on Cardiovascular Risk in Patients with Rheumatoid Arthritis. Cells. 2021 May 7;10(5):1131. doi: 10.3390/cells10051131.

Reference Type: DERIVED

PMID: 34067093 (View on PubMed)

Nadali M, Lyngfelt L, Erlandsson MC, Silfversward ST, Andersson KME, Bokarewa MI, Pullerits R. Low Soluble Receptor for Advanced Glycation End Products Precedes and Predicts Cardiometabolic Events in Women With Rheumatoid Arthritis. Front Med (Lausanne). 2021 Jan 28;7:594622. doi: 10.3389/fmed.2020.594622. eCollection 2020.

Reference Type: DERIVED

PMID: 33585503 (View on PubMed)

Other Identifiers

RÖK

Identifier Type: -

Identifier Source: org_study_id