14-3-3η Protein, Disease Activity and Bone Mineral Density, in Female Patients With Rheumatoid Arthritis

NCT ID: NCT03999528

Last Updated: 2020-06-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

45 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-05-01

Study Completion Date

2019-08-01

Brief Summary

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Is to investigate the relation between 14-3-3η protein, disease activity, and bone mineral density in female patients with rheumatoid arthritis.

Detailed Description

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Methods: all patients in the study will subject to:

* Clinical assessment, WT, Height ,BMI, parity, medications,
* DAS 28.
* Serum 14-3-3η protein.
* DEXA scan.

Grouping:

* Group I: RA Patients with low BMD.
* Group II: RA Patients with normal BMD.
* Group III: normal control.

Conditions

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Rheumatoid Arthritis Osteoporosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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study group

RA Patients

14-3-3η Protein assay

Intervention Type DIAGNOSTIC_TEST

blood sampling for assessment of serum 14-3-3η Protein

control group

normal control

14-3-3η Protein assay

Intervention Type DIAGNOSTIC_TEST

blood sampling for assessment of serum 14-3-3η Protein

Interventions

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14-3-3η Protein assay

blood sampling for assessment of serum 14-3-3η Protein

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Rheumatoid arthritis according to ACR 2010 criteria with at least one year duration.
* Premenopausal females.
* On conventional DMARD with maximum 5 mg steroids.

Exclusion Criteria

* Biological treatment.
* Previous antiresorptive treatment, or bone anabolics.
* High dose corticosteroid.
* Chronic renal or kidney disease.
* Medications affecting bone metabolism.
* Thyroid or adrenal dysfunction,
Minimum Eligible Age

16 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Al-Azhar University

OTHER

Sponsor Role lead

Responsible Party

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Ahmed Abogamal

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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AHMED ABOGAMAL

Role: STUDY_CHAIR

Al-Azhar Faculty of medicine- Cairo

Locations

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Al-Azhar Faculty of medicine, Rheumatology Department

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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Rheu-med.9med.research

Identifier Type: -

Identifier Source: org_study_id

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