The Impact of Glycemic Control on Rheumatoid Arthritis Disease Activity on Diabetic Patients

NCT ID: NCT06691997

Last Updated: 2024-11-18

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-12-12
• Study Completion Date: 2027-06-01

Brief Summary

The incidence of DM is unclear in RA but most prior data suggest that DM or insulin resistance in RA has risen because of activation of the immune system and/or RA therapy .

Besides, RA causes joints to become stiff, swollen, and agonizing. As a result, the patient may not want to exercise or move. One study found that 42% of people with RA are not physically active. the aim of this study is To evaluate the glycemic status among RA patients with Type 2 diabetes and its association with disease activity.

Detailed Description

Taking the potential link between DM and RA into consideration, detection and control of DM will significantly increase prolonged prognosis and therefore decrease the economic burden of RA patients and death rate. The aim of this research is to examine diabetic RA's glycemic status and to assess the relationship between RA and DM's clinical characteristics as well as the therapy response in RA patients with diagnosed DM. Keeping an eye on glycemic control in RA patients could prevent metabolic and cardiovascular comorbidities in those susceptible patients.

Conditions

Rheumatoid Arthritis (RA; Diabetes Mellitus

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

group 1

RA patients with Type 2 diabetes

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• type 2 diabetic patients
• rheumatoid arthritis patients

Exclusion Criteria

• gestional diabetes
• type 1 diabetic patients

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Ahmed Khedr Nady Abd Elaziz

Assistant lecture

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ahmed khedr Nady

Role: PRINCIPAL_INVESTIGATOR

Assiut University

Locations

Assiut university

Asyut, , Egypt

Countries

Egypt

Central Contacts

Ahmed khedr Nady

Role: CONTACT

ahmed.16266234@med.aun.edu.eg

+201097613616

Eman Mohamed Ibrahim, Lecturer

Role: CONTACT

emanmibrahem@aun.edu.eg

+201007179120

Related Links

https://pubmed.ncbi.nlm.nih.gov/29671563/

Wasserman A. Rheumatoid Arthritis: Common Questions About Diagnosis and Management. Am Fam Physician. 2018 Apr 1;97(7):455-462. PMID: 29671563.

https://pubmed.ncbi.nlm.nih.gov/33060323/

Almutairi KB, Nossent JC, Preen DB, Keen HI, Inderjeeth CA. The Prevalence of Rheumatoid Arthritis: A Systematic Review of Population-based Studies. J Rheumatol. 2021 May;48(5):669-676. doi: 10.3899/jrheum.200367. Epub 2020 Oct 15. PMID: 33060323.

https://pubmed.ncbi.nlm.nih.gov/20872595/

Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Meas

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015093/

Schoels M, Knevel R, Aletaha D, Bijlsma JWJ, Breedveld FC, Boumpas DT, Burmester G, Combe B, Cutolo M, Dougados M, Emery P, van der Heijde D, Huizinga TWJ, Kalden J, Keystone EC, Kvien TK, Martin-Mola E, Montecucco C, de Wit M, Smolen JS. Evidence for tr

https://pubmed.ncbi.nlm.nih.gov/25535750/

Jiang P, Li H, Li X. Diabetes mellitus risk factors in rheumatoid arthritis: a systematic review and meta-analysis. Clin Exp Rheumatol. 2015 Jan-Feb;33(1):115-21. Epub 2014 Dec 22. PMID: 25535750.

Other Identifiers

DM and Rheumatoid Arthritis

Identifier Type: -

Identifier Source: org_study_id