Triosephosphate Isomerase Level in Relation to Rheumatoid Aerthritis Activity and Structural Damage

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-09-30

Study Completion Date

2027-10-31

Brief Summary

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1. Assess the serum level of TPI in patients with RA compared to healthy controls.
2. Correlate serum level of TPI and disease activity.
3. Correlation of serum TPI level with US7 damage index

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Detailed Description

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Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent synovial inflammation, synovial hyperplasia, and progressive destruction of bone and cartilage. These pathological processes can lead to joint deformities and loss of function, significantly affecting patients' quality of life. In addition to joint damage, RA often manifests with extraarticular complications involving the cardiovascular, pulmonary, and other organ systems. These systemic effects impose a substantial burden on patients' physical and mental well-being, as well as their socioeconomic status .The disease often affects subjects between the ages of 40 and 70; however, it can also occur at a younger age. Globally, the prevalence rate of RA is approximately 1%, with females experiencing a higher incidence . Triosephosphate isomerase (TPI) is a metabolic enzyme that regulates the flow of glycolysis and energy generation by converting dihydroxyacetone phosphate (DHAP) into D- glyceraldehyde 3-phosphate (G3P). TPI is one of the glycolytic enzymes implicated in the pathogenesis of RA.

Additionally, it has been shown to possess functions beyond glycolysis, including potential roles in the nucleus related to cancer pathogenesis and chemotherapy resistance . Some studies showed a significant correlation between elevated TPI levels and RA, with TPI serving as an independent predictor of the disease. With some findings, which include a high sensitivity of 98.5% and specificity of 100%, suggest that TPI could be a valuable biomarker for the early diagnosis and management of RA

Conditions

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Rheumatoid Arthritis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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cases

Rheumatoid Arthritis pateints

serum TPI

Intervention Type DIAGNOSTIC_TEST

serum TPI level

controls

healthy controls

serum TPI

Intervention Type DIAGNOSTIC_TEST

serum TPI level

Interventions

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serum TPI

serum TPI level

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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ultrasound

Eligibility Criteria

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Inclusion Criteria

\- Adult patients with RA who fulfill 2010 ACR/EULAR classification criteria

Exclusion Criteria

1. Individuals with uncontrolled chronic diseases such as hypertension , diabetes, heart disease, liver or kidney disease, other autoimmune disorders and tumors.
2. Pregnant women.
3. Rheumatologic diseases other than RA

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No