Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2013-07-31

Brief Summary

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The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.

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Detailed Description

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Conditions

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Myocardial Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Investigators

Study Groups

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ExerciseTr

Group Type EXPERIMENTAL

Exercise training

Intervention Type BEHAVIORAL

exercise training

Remote ischemic preconditioning group

Group Type EXPERIMENTAL

remote ischemic preconditioning

Intervention Type PROCEDURE

remote ischemic preconditioning

Control patient group

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise training

exercise training

Intervention Type BEHAVIORAL

remote ischemic preconditioning

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing coronary heart surgery and heart transplantation

Exclusion Criteria

* myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin \> 140)

Eligible Sex

ALL

Accepts Healthy Volunteers

No