Norwegian Cardio-Respiratory Arrest Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

261 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-09-30

Study Completion Date

2028-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to evaluate the use of combined clinical-neurological, neurophysiologic, neuroradiological and biochemical markers in prognostication after cardio- and/or respiratory arrest.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Quality of Cardiopulmonary Resuscitation Pre- and Intra Hospital

NCT04295291

Cardiac Death Cardiac Arrest Cardiac Arrhythmia +1 more

NOT_YET_RECRUITING

Transitions Between Clinical Circulatory States After Out-of-hospital Cardiac Arrest

NCT02648061

Out-of-Hospital Cardiac Arrest

COMPLETED

Blood Pressure and Cerebral Blood Flow After Cardiac Arrest

NCT05434910

Out-Of-Hospital Cardiac Arrest Post-Cardiac Arrest Syndrome

UNKNOWN NA

Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest

NCT06979700

Cardiac Arrest (CA) Anoxic Brain Injury Comatose Survivors of Cardiac Arrest +5 more

RECRUITING

Evaluation of the Quality of Cardio-Pulmonary Resuscitation (CPR) in Cardiac Arrest Patients

NCT00951704

Cardiac Arrest

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Cardiac arrest (CA) is a leading cause of death, affecting about 700.000 individuals each year in Europe. Acute Myocardial Infarction (AMI) and primary arrhythmia are the most common causes of CA, whereas respiratory arrest is a leading cause of secondary CA. Patients who have undergone cardiopulmonary resuscitation (CPR) often remain unconscious after hospital admission, either as a result of severe permanent brain damage or a merely reversible metabolic disturbance due to post-ischemic global reperfusion. Early prediction of neurological and cardiac outcome remains a difficult task for physicians. The decision to continue, limit or terminate intensive care therapy carries huge ethical and socioeconomic implications. Optimal emergency cardiovascular care, cardiac failure therapy and CA prevention after hospitalisation also remain difficult issues for cardiologists and intensive care doctors.

In this prospective study running from 2010, both prognostication and in-hospital treatment are studied in a population of 261 patients with out-of-hospital cardio-respiratory arrest. The use of combined clinical-neurological, neurophysiologic, neuroradiological and biochemical markers is studied to asses whether a poor neurological outcome (Cerebral Performance Category 3-5) can be predicted with \~100% specificity and a sensitivity that is sufficient for practical clinical use.

Pre-disposing and triggering causes of cardiorespiratory arrest are also registered. Patients with pre-existing conditions coherent with prophylactic ICD implementation under current international guidelines will be identified, in order to assess and further improve ICD-prophylactic treatment in Norway. The potential benefit of invasive PICCO-monitoring after CA will also be evaluated, and a subproject identifying biomarkers for CA risk has been established. NIRS (Near-Infrared spectroscopy) will also be used to register cerebral oxygenation in the early days after cardiorespiratory arrest.

The overall aim of the NORCAST study is to provide physicians with better tools to asses cardiac and neurological outcome as early and as accurate as possible.

All alive study patients are invited to long-term follow-up consultaions after 6 months, after 4 years, and after 10 years. The consultations will include study examinations, structured interviews and questionnaires. Questionnaires will also be used for next of kin.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cardiac Arrest Respiratory Arrest Coma

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* prehospital cardial resuscitation
* prehospital pulmonary resuscitation
* ROSC before/on admission to hospital
* \> 18 years of age

Exclusion Criteria

* death on admission to hospital
* arrhythmic cardiac arrest with ALS \< 5min and spontaneous awakening
* in-hospital cardiac arrest
* trauma patients

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No