Optic Nerve Sheath Diameter for Prediction of Outcome After Cardiac Arrest

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

36 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-11-30

Study Completion Date

2014-01-31

Brief Summary

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Early prognostication in resuscitated cardiac arrest (CA) patients, within the first day after admission in the intensive care unit (ICU), remains difficult. Optic nerve sheath diameter (ONSD) measurement could predict increased intracranial pressure. Preliminary works showed that ONSD measurement could be used to predict outcome in post-CA patients.

The aim of this study was to assess the ability of bedside ONSD ultrasonographic measurement to predict survival and Cerebral Performance Category (CPC) score at hospital discharge in post-cardiac arrest patients treated with therapeutic hypothermia (TH).

Detailed Description

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Prospective observational study including all consecutive successfully resuscitated and TH-treated CA patients without traumatic or neurological etiology of CA in two French ICUs. ONSD measurements were performed on day 1, 2, and 3 after return of spontaneous circulation (ONSD1,2,3 respectively).

The primary outcome is survival at hospital discharge (with an average follow-up of 3 month until ICU admission).

Conditions

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Cardiac Arrest

Keywords

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Cardiac arrest neuroprognostication optic nerve sheath diameter outcome ultrasonography

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Unconscious (Glasgow Coma Scale ≤6)
* ≥18 years old
* Admitted in ICU after successful resuscitation from CA
* Treated with TH targeted to 33°C

Exclusion Criteria

* unavailable ONSD measurement within 24 hours after return of spontaneous circulation (unavailable investigator, early death, or major hemodynamic instability)
* Traumatic or neurological origin of CA
* Previous cerebrovascular disease
* Facial trauma affecting the orbits and/or eyeballs
* Previous history of ocular pathology such as exophthalmia, glaucoma or cataract.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Chelly Jonathan

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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MelunH

Identifier Type: -

Identifier Source: org_study_id