Regulation of Endothelial Progenitor Cells by Short-Term Exercise

NCT ID: NCT01169831

Last Updated: 2024-08-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2011-07-31
• Study Completion Date: 2024-07-31

Brief Summary

Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and function in old vs. young individuals, and endurance exercise training increases EPC number and function in young adults. Oxidative stress adversely affects endothelial cells and preliminary evidence indicates that oxidative stress negatively affects EPC function. Conversely, regular exercise reduces markers of oxidative stress and may enhance EPC function in older adults. The investigators hypothesize that older endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC function and that altering the physical activity levels of both groups will move them to intermediate points between these two extremes. The investigators also propose that the investigators can "mimic" the effect of exercise training on EPC function in cell culture by altering intracellular levels of a key enzyme and a signaling molecule which the investigators have shown to regulate EPC function with respect to exercise training in young individuals.

Conditions

Aging; Exercise; Cardiovascular Disease

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Sedentary Older Adults

Group Type: EXPERIMENTAL

Exercise Training

Intervention Type: OTHER

2 weeks of daily aerobic exercise training

Older Endurance Athletes

Group Type: EXPERIMENTAL

Exercise Cessation

Intervention Type: OTHER

Stopping all exercise for 2 weeks

Interventions

Exercise Training

2 weeks of daily aerobic exercise training

Intervention Type: OTHER

Exercise Cessation

Stopping all exercise for 2 weeks

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• 50-80 years of age, BMI = 18-35 kg/m2, non-smoking, women must be postmenopausal

Exclusion Criteria

• history of cardiovascular/cerebrovascular disease, diabetes, cancer, renal, liver disease, HIV; uncontrolled hyperlipidemia/hypertension

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Maryland, Baltimore

OTHER

Sponsor Role: collaborator

University of Maryland, College Park

OTHER

Sponsor Role: collaborator

Baltimore VA Medical Center

FED

Sponsor Role: lead

Responsible Party

Steven J. Prior, Ph.D.

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Steven J Prior, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Maryland, Baltimore

Locations

University of Maryland, Baltimore & Baltimore VA Medical Center

Baltimore, Maryland, United States

Countries

United States

Other Identifiers

HP-00045413

Identifier Type: -

Identifier Source: org_study_id