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Impact of Exercise Training on Endothelial Function in CAD

NCT ID: NCT00176345

Last Updated: 2005-09-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2001-01-31

Brief Summary

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Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promoting a vasodilatory respone. Regular physical exercise training results in an improvement of endothelial function in patients with CAD. These positive effects were partially attributed to an increased expression of endothelial NO synthase (eNOS) and cyclooxygenase (COX) as a result of the training intervention.

Aim of this trial is therefore to determine, whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent.

Detailed Description

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A total of 20 patients with stable coronary artery disease are prospectively randomized to 4 weeks of exercise training or sedentary lifestyle.

Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound.

Conditions

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Coronary Artery Disease

Keywords

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exercise training endothelial function

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

ECT

Blinding Strategy

NONE

Interventions

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Exercise Training

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* stable CAD
* male gender

Exclusion Criteria

* insulin-dependent diabetes mellitus
* significant valvular heart disease
* smoking
* exercise-induced myocardial ischemia
* conditions prohibiting exercise training
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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University of Leipzig

OTHER

Sponsor Role lead

Principal Investigators

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Rainer P Hambrecht, MD

Role: PRINCIPAL_INVESTIGATOR

University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology

Locations

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University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology

Leipzig, Saxony, Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Rainer P Hambrecht, MD

Role: CONTACT

Phone: ++49-341 865

Email: [email protected]

Sandra Erbs, MD

Role: CONTACT

Phone: ++49-341 865

Email: [email protected]

Facility Contacts

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Rainer P Hambrecht, MD

Role: primary

Sandra Erbs, MD

Role: backup

Other Identifiers

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157/02

Identifier Type: -

Identifier Source: secondary_id

639/97

Identifier Type: -

Identifier Source: org_study_id