Exercise to Slow Cardiovascular Ageing Progression

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

450 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-05-01

Study Completion Date

2050-12-31

Brief Summary

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In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.

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Detailed Description

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Participants from each stratum will be randomized to receive either an exercise program intervention or no exercise. At the start and end of study, participants will undergo cardiovascular imaging and metabolic profiling. Investigators will determine if exercise can reverse high-risk metabolic profiles and improve cardiovascular structure and function.

Without clear mechanisms to explain cardiovascular ageing nor interventions known to retard cardiovascular ageing, our approach will provide much needed translational evidence to incorporate targeted interventions aimed at reducing cardiovascular disease risk in older populations.

Conditions

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Cardiac Ageing Exercise Cardiovascular

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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A

1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography
2. Bio-specimen collection
3. Six-minute walk test
4. Musculoskeletal Analysis
5. Cardiopulmonary exercise test

No interventions assigned to this group

B

1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography
2. Bio-specimen collection
3. Six-minute walk test
4. Musculoskeletal Analysis

No interventions assigned to this group

C

1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography
2. Bio-specimen collection
3. Six-minute walk test
4. Musculoskeletal Analysis

No interventions assigned to this group

D

1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography
2. Bio-specimen collection
3. Six-minute walk test (may require separate day visit to complete)
4. Musculoskeletal Analysis
5. Questionnaires

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age \>=21 years old
* Outdoor ambulant

Exclusion Criteria

* Wheelchair or bed-bound
* Dementia
* Residing in sheltered or nursing home
* Cancer
* Participation in ongoing clinical trials that involve interventional drugs or devices
* Aneurysms
* Acute infections (in the last six months)
* Uncontrolled thyrotoxicosis
* Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise
* Uncontrolled asthma or chronic lung disease
* Restrictive lung disease

Minimum Eligible Age

21 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes