Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
NCT ID: NCT01083901
Last Updated: 2013-06-24
Study Results
Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.
View full resultsBasic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
34 participants
INTERVENTIONAL
2006-05-31
2011-03-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Comparing the Effects of Upper and Lower Body Resistance Training on Pain Sensitivity
NCT05985382
Assessing the Impact of Age, and a Short-term High-intensity Interval Training (HIIT) on Skeletal Muscle Mass and Mitochondrial Activity
NCT05934760
Healthy Aging Through Optimized Exercise
NCT07093216
A Study to Assess Effect of Exercise Program Provided by Smartphone Application on the Body Composition
NCT04194697
Resistance-type Exercise Training in the Older Population
NCT04999501
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
To test the hypothesis that acetaminophen and ibuprofen would diminish training-induced increases in fat-free mass, untrained men (n=26) aged ≥ 50 years participated in 16 weeks of high-intensity progressive resistance exercise training and bone-loading exercises and were randomly assigned to take ACET (1000 mg), ibuprofen (400 mg) or placebo 2 hours before each exercise session.
The primary outcome was the change in total body fat-free mass measured by dual-energy X-ray absorptiometry (DXA) at baseline and week 16. Our primary interest was in the comparison of the acetaminophen and placebo groups.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TRIPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Resistance training with Acetaminophen
Acetaminophen
Resistance training
high intensity progressive resistance exercise training
Resistance Training with ibuprofen
Ibuprofen
Resistance training
high intensity progressive resistance exercise training
placebo
Placebo
Resistance training
high intensity progressive resistance exercise training
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Resistance training
high intensity progressive resistance exercise training
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* not currently engaged in moderate-to-vigorous weight-lifting exercise
* non-smoker
* willing to participate in a supervised exercise program for 9 months
Exclusion Criteria
* contraindications to exercise testing and training including congestive heart failure class III or IV, uncontrolled hypertension and unstable cardiovascular disease
* thyroid dysfunction
* orthopedic problems that limit the ability to perform vigorous exercise or increase the likelihood of the use of pain medications
* drugs known to alter bone metabolism
* allergy to lidocaine
* diabetes mellitus requiring pharmacologic therapy
50 Years
MALE
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
National Institute on Aging (NIA)
NIH
University of Colorado, Denver
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Catherine Jankowski, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Colorado, Denver
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
University of Colorado Denver
Aurora, Colorado, United States
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
06-0343
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.