Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE1
20 participants
INTERVENTIONAL
2010-02-28
2010-10-31
Brief Summary
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Detailed Description
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In heart failure, a condition where the heart muscle is damaged and can not pump as well, this reflex is exaggerated. The result of this can be breathing conditions characterised by patients hyperventilating at times and at other times taking very shallow breaths or even stopping altogether. In the past the only way of measuring this chemoreflex was to get patients to breathe into a large container and to rebreathe their exhaled air and allow the CO2 to rise over time, whilst keeping the oxygen constant. The proportion by which the ventilation increases with increasing carbon dioxide is the chemoreflex gain. Unfortunately, because this test takes a long time to conduct, requires specialist knowledge and equipment it has not been possible to measure this reflex on exercise.
Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
NONE
Interventions
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carbon dioxide
sinusoidal carbon dioxide delivery
Eligibility Criteria
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Inclusion Criteria
* Heart Failure Subjects: Males aged 18-80 with a clinical diagnosis of heart failure who are able to perform both running and cycling and can follow simple visual instructions.
Exclusion Criteria
* Pulmonary oedema,
* Uncontrolled hypertension (systolic blood pressure \> 220 mm Hg, diastolic \>120 mm Hg),
* Severe aortic stenosis,
* Severe hypertrophic obstructive cardiomyopathy,
* Untreated life threatening arrhythmia,
* Dissecting aneurysm,
* Recent surgery (within 4-6 weeks), COPD.
18 Years
80 Years
MALE
Yes
Sponsors
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Imperial College London
OTHER
Responsible Party
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Imperial College
Locations
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St Mary's Hospital
Paddington, London, United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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10/H0712/9
Identifier Type: -
Identifier Source: org_study_id
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