Sympathetic Neural Outflow During Xenon Anesthesia in Humans

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-01-31

Study Completion Date

2010-03-31

Brief Summary

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The purpose of this study is to test the hypothesis that sympathetic neural outflow to muscles as well as a sympathetic baroreflexes are not altered during xenon anesthesia in Healthy Volunteers.

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Detailed Description

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Objectives for this study :

* Main Objective : Influence of Xenon anesthesia on Sympathetic Nervous Activity
* Secondary Objectives : Security under LENOXe™ (xénon 100 % v/v) anesthesia

Conditions

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Sympathetic Nervous System

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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LENOXe™ (xénon 100 % v/v)

Influence of LENOXe™ (xénon 100 % v/v) anesthesia on Sympathetic Nervous Activity and Security under LENOXe™ (xénon 100 % v/v) anesthesia

Group Type EXPERIMENTAL

xenon

Intervention Type DRUG

Inhalational gas; dose allowed max.70 Vol.% in 30 % oxygen; the duration of the treatment will be to 30 minutes

Interventions

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xenon

Inhalational gas; dose allowed max.70 Vol.% in 30 % oxygen; the duration of the treatment will be to 30 minutes

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers \> 18 years and \< 65 years of age
* ASA physical status I
* Legal competence
* for whom the consent form has been signed

Exclusion Criteria

* Healthy volunteers \< 18 years and \> 65 years of age
* Pregnancy, lactation period or missing secure anticonvulsive therapy
* Missing legal competence
* Participation in other clinical trials
* Contraindications as mentioned on §4.3 of the SPCs of LENOXe™ (xénon 100 % v/v)
* Any medication especially of Sildenafil (Viagra®) or other potency remedy
* Existing relationship of dependency to the sponsor or the investigator

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No