Dietary Lipids as Primary Modulators of Carotenoid Absorption in Vegetables

NCT ID: NCT01006174

Last Updated: 2013-01-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

55 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-03-31

Study Completion Date

2010-05-31

Brief Summary

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The purpose of this research study is to determine how dietary fats and oils influence the absorption of beneficial plant pigments (carotenoids) from vegetables. The study will examine changes in blood carotenoids in response to eating a salad with different fats/oils.

Detailed Description

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Conditions

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Absorption of Carotenoids From Vegetables

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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A

Subjects will be assigned to consume 3 grams soybean oil, 8 grams canola oil, and 20 grams butter that is added to a salad.

Group Type EXPERIMENTAL

Soybean Oil

Intervention Type OTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of soybean oil that is added to a salad.

Canola Oil

Intervention Type OTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of canola oil that is added to a salad.

Butter

Intervention Type OTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of butter that is added to a salad.

B

Subjects will be assigned to consume 8 grams soybean oil, 20 grams canola oil, and 3 grams butter that is added to a salad.

Group Type EXPERIMENTAL

Soybean Oil

Intervention Type OTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of soybean oil that is added to a salad.

Canola Oil

Intervention Type OTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of canola oil that is added to a salad.

Butter

Intervention Type OTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of butter that is added to a salad.

C

Subjects will be assigned to consume 20 grams soybean oil, 3 grams canola oil, and 8 grams butter that is added to a salad.

Group Type EXPERIMENTAL

Soybean Oil

Intervention Type OTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of soybean oil that is added to a salad.

Canola Oil

Intervention Type OTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of canola oil that is added to a salad.

Butter

Intervention Type OTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of butter that is added to a salad.

Interventions

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Soybean Oil

Depending on the experimental group assigned, each subject which will be given one of three different amounts of soybean oil that is added to a salad.

Intervention Type OTHER

Canola Oil

Depending on the experimental group assigned, each subject which will be given one of three different amounts of canola oil that is added to a salad.

Intervention Type OTHER

Butter

Depending on the experimental group assigned, each subject which will be given one of three different amounts of butter that is added to a salad.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age range: 18-50 years.
* Body mass index (BMI: weight (kg)/height (m2)) ranging from 20-29 kg/m²
* Weight stable (\<4.5 kg change within the last 3 months),
* Constant habitual activity pattern, not to exceed activities of a recreational level over the past 3 months.
* Must be pre-menopausal
* Have clinically normal blood profiles (specifically normal liver and kidney functions and fasting blood glucose of ≤110 mg/dl)
* Non-smoking
* Non-diabetic
* No current or planned pregnancy
* Not using any hormone-based contraceptive, e.g., pill, patch, injection, implants, etc.
* No current use of medication affecting lipid profile
* No intestinal disorders including lipid malabsorption, lactose intolerance
* No heavy consumption of alcohol (\>2 drinks per day)
* No current use of dietary supplements that affect cholesterol, (e.g. Benocol or fiber supplements) or a willingness to discontinue their use during the study.

Exclusion Criteria

* Menopausal
* Diabetic
* Currently pregnant
* Currently using any type of hormone-based contraceptives, (e.g., pill, patch, injection, implants, etc.)
* Use of lipid altering medications
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Purdue University

OTHER

Sponsor Role lead

Responsible Party

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Wayne Campbell

Wayne Campbell, Ph.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Purdue University

West Lafayette, Indiana, United States

Site Status

Countries

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United States

Other Identifiers

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0707005641

Identifier Type: -

Identifier Source: org_study_id

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